Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep851 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pachydermaperiostosis: a rare syndrome presented with acromegaloid changes

Uygur Meliha Melin , Arikan Izzet Hakki , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Pachydermoperiostosis (PDP) is a rare hereditary syndrome with familial and idiopathic forms that is characterized by subperiosteal new bone formation with pain, polyarthritis, cutis vertices grata, seborrhea, hyperhidrosis and digital clubbing. Periostosis and cutaneous thickening along with the absence of any signs of cardiovascular, pulmonary, hepatic, intestinal and mediastinal diseases causing secondary hypertrophic osteoarthropathy suggest PDP. The incidenc...

ea0041ep110 | Bone & Osteoporosis | ECE2016

Clinical characteristics of Paget disease of bone from Turkey

Yavuz Dilek Gogas , Ayturk Semra , Bayraktar Firat , Cetinkalp Sevki , PD Study Group

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...

ea0041ep144 | Calcium and Vitamin D metabolism | ECE2016

Bone mineral density is associated with hypercalciuria in primary hyperparathyroidism

Yavuz Dilek Gogas , Tekin Bahar , Buket Bayram F. , Melin Uygur M.

Aim: The most common clinical presentation of primary hyperparathyroidism (PHPT) is asymptomatıc and it is diagnosed incidentally without developing complications.In our study, we aimed to examine the characteristics of participants with primary hyperparathyroidism and the relationship between bone mineral density (BMD) and hypercalciuria.Methods: Consecutive 191 normocalciuric (24-h urinary calcium<400 mg/day) patients with PHPT (51±13 yea...

ea0041ep145 | Calcium and Vitamin D metabolism | ECE2016

Bone mineral density measurement in newly diagnosed primary hyperparathyroidism patients

Tekin Bahar , Melin Uygur M. , Buket Bayram F. , Yavuz Dilek Gogas

Aim: Clinical presentation of primary hyperparathyroidism (PHPT) differs between populations. In this study, we aimed to examine bone mineral density (BMD) and bone metabolism parameters in newly diagnosed and untreated PHPT patients in a single endocrine center in İstanbul, Turkey.Methods: Consecutive 256 PHPT patients (50.7±14 years, F/M:205/51) and 89 healthy controls (38.8±10 years, F/M:67/22) were included in the study. Serum calcium...

ea0032p848 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Advanced glycation end product associated skin autofluorescence and serum corboxymethyl lysine levels in acromegaly

Yavuz Dilek Gogas , Yalin Serap , Yazici Dilek , Yasar Mehmet , Deyneli Oguzhan

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...

ea0022p147 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Gender variations of serum Paraoxonase-1 activities in healthy young men and women: association with carotid intimae media thickness

Yavuz Dilek Gogas , Tarcin Ozlem , Gun Palmet , Sirikci Onder , Akalin Sema

Aim: Paraoxonase-1 (PON-1), an HDL-associated enzyme has been shown to possess antioxidant properties that protect against atherosclerosis. The aim of this study is to evaluate serum paraoxanase activities, lipid profiles and carotid intimae media thickness (CIMT) as an early marker of atherosclerosis in healthy man and women.Method: Four hundred healthy volunteers (F/M: 250/150, 19–23 years) included in the study. Serum paraoxonase and arylesterase...

ea0020p195 | Endocrine tumours and neoplasia | ECE2009

Microalbuminuria and insulin resistance in nondiabetic acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Yavuz Dilek Gogas , Akalin Nefise Sema

Growth hormon (GH) counteracts the effects of insulin on glucose metabolism and GH excess may lead to insulin resistance (IR). Impaired glucose tolerance (IGT) and diabetes mellitus (DM) are frequently associated with acromegaly. Microalbuminuria (MAU) is a well established cardiovascular (CV) risk factor and a predictor of CV mortality in both diabetic and nondiabetic subjects.The aim of this preliminary study was to investigate the MAU levels as a mark...

ea0020p375 | Diabetes and Cardiovascular | ECE2009

ECoRI polymorphism but not XBaI polymorphism of apolipoprotein B gene is associated with carotis intima media thickness in type 2 diabetic patients

Yuksel Meral , Sancak Seda , Yazici Dilek Dereli , Ozben Beste , Gogas-Yavuz Dilek , Akalin Nefise Sema

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p415 | (1) | ECE2007

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Yazici Dilek , Tarcin Ozlem , Ozben Beste , Toprak Ahmet , Deyneli Oguzhan , Sancak Seda , Yavuz Dilek , Akalin Sema

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...