Searchable abstracts of presentations at key conferences in endocrinology

ea0050p016 | Adrenal and Steroids | SFEBES2017

The potential use of I-131 Norcholesterol scan for large adrenal mass

Alnaim Abdulrhman , Wan Ming Young Simon , Abdel-Aziz Tarek Ezzat , Chung Teng-Teng , Kurzawinski Tom , Bomanji Jamshed

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

ea0050p390 | Thyroid | SFEBES2017

Thyrotrophin receptor antibodies (TRAb) and other autoantibodies after treatment of Graves’ disease

Nalla Preethi , Young Stuart , Sanders Jane , Adlan Mohamed , Furmaniak Judwiga , Chen Shue , Rees Smith Bernard , Premawardhana Lakadasa

Introduction: Following treatment of Graves’ disease (GD), levels of thyrotropin receptor autoantibodies (TRAb) tend to decrease depending on treatment modality and length of follow up. We have assessed TRAb biological activity at follow up, years after GD treatment.Subjects and methods: TRAb concentration and biological activity were measured in 69 GD patients (59 females; 10 males; median age 59 years; TRAb positive at diagnosis), with follow up r...

ea0086p30 | Bone and Calcium | SFEBES2022

Recognition and acute management of parathyroid crisis; early localization and surgery

Young Ekenechukwu , Varghese Jeanny , Bell Richard , Kong Ngai , Bhathia Praveen , Selby Peter , Jackson Matthew , Ahmed Mariyah , Forgacs Bence , Pulman Samuel

Background: Parathyroid crisis is a rare presentation with high mortality if unrecognized. Early surgery is curative with rapid symptom resolution and improved outcomes.Case Report: We describe a case of severe hypercalcaemia due to primary hyperparathyroidism in a 59 year old male who presented with symptoms of lethargy, confusion, reduced appetite, constipation, light headedness and vomiting. Clinical examination was unremarkable. He had normal inflamm...

ea0090p572 | Calcium and Bone | ECE2023

Similarities and differences between thyroid and parathyroid nodules on ultrasound: the PARATH-US study

Yazgi Dolly , Richa Carine , Salenave Sylvie , Kamenicky Peter , Bourouina Amel , Clavier Lorraine , Young Jacques , Chanson Philippe , Maione Luigi

Context: Cervical ultrasound is a frequently used and an accessible operator-dependent tool, which contributes to the characterization of thyroid nodules and to the preoperative localization of pathological parathyroid glands. However, thyroid nodules may be confused with parathyroid lesions. There is no study directly comparing thyroid and parathyroid nodules on ultrasound.Objectives: 1) To describe the ultrasonographic characteristics of parathyroid le...

ea0090p465 | Reproductive and Developmental Endocrinology | ECE2023

Sexual dimorphism in the LH responses to kisspeptin and senktide administration in prepubertal mice

Maione Luigi , Naule Lydie , Yang Ling Li Chloe , Magnuson Melissa , Young Jacques , Stephanie Carroll Rona , Kaiser Ursula

Introduction: The hypothalamic-pituitary-gonadal (HPG) axis is regulated by pulsatile GnRH secretion and its action on the anterior pituitary, leading to the synthesis and secretion of LH and FSH. KNDy neurons, expressing kisspeptin, neurokinin B and dynorphin A, are the GnRH/lH pulse generator and are key regulators of puberty and fertility. The HPG axis is active during prenatal and early postnatal life in humans and rodents, but then remains quiescent until puberty in both ...

ea0063p308 | Reproductive Endocrinology 1 | ECE2019

Reproductive phenotype in 265 men with congenital hypogonadotropic hypogonadism and 531 men with acquired hypogonadotropic hypogonadism: a monocentric comparative study

Maione Luigi , Sarfati Julie , Bernard Valerie , Gonfroy Celine , Jublanc Christel , Salenave Sylvie , Trabado Severine , Chanson Philippe , Young Jacques

Context: Hypogonadotropic hypogonadism (HH), defined by LH and FSH deficiencies, lead to impairment in testicular growth, testicular hormonal secretions and spermatogenesis. HH can have a prenatal (congenital HH, CHH) or post-natal (acquired HH, HHA) onset. Direct comparison of reproductive phenotypes (RP) between CHH and AHH has not been systematically performed in large series representative of these two populations.Patients and methods: 60 normal men,...

ea0049ep1015 | Pituitary - Clinical | ECE2017

Osilodrostat maintains normalized urinary free cortisol levels in a majority of patients with Cushing’s disease: Long-term results from an extension to the LINC-2 study

Young Jacques , Hatipogulu Betul , Molitch Mark E , Bertagna Xavier , Barbier Nathalie , Sauter Nicholas , Biller Beverly M K , Pivonello Rosario

Background: In the 22-week LINC-2 study, osilodrostat (LCI699), a potent oral 11β-hydroxylase inhibitor, normalized urinary free cortisol (UFC) levels in 15 of 19 patients with Cushing’s disease (CD). The most common AEs were nausea, diarrhea, asthenia, and adrenal insufficiency (n=6 each). Here, we report the 31-month efficacy and safety results from LINC-2 extension.Methods: Patients receiving clinical benefit at week 22 could enter ...

ea0044p130 | Neoplasia, cancer and late effects | SFEBES2016

Diagnostic performance of adrenal imaging in a high risk population for adrenal malignancy

Delivanis Danae , Nathan Mark , Atwell Thomas , Eiken Patrick , Schmit Grant , Natt Neena , Erickson Dana , Maraka Spyridoula , Young William , Bancos Irina

Objective: There is limited evidence on the diagnostic accuracy of imaging tests in patients at high risk for adrenal malignancy. Our objective was to determine the performance of computed tomography (CT) and 18FDG-PET/CT imaging in diagnosing a malignant adrenal mass in a high risk population of patients referred for CT-guided adrenal biopsy.Methods: We retrospectively reviewed the medical records of 378 patients who had percutaneous adrenal ...

ea0041ep1095 | Thyroid cancer | ECE2016

Clinical usefulness of dynamic risk stratification in medullary thyroid cancer

Han Ji Min , Kwon Hyemi , Kim Won Gu , Jeon Min Ji , Kim Tae Yong , Kim Won Bae , Shong Young Kee

Purpose: To detect persistent/recurrent disease of medullary thyroid carcinoma (MTC) after initial surgery is important. The Tumor-Node-Metastasis (TNM) staging system is useful for predicting disease-specific mortality, but it is static and does not include postoperative serum calcitonin levels. We focused on the clinical usefulness of dynamic risk stratification (DRS) using the best response to initial therapy in patients with MTC.Methods: A total of 1...

ea0037ep585 | Obesity and cardiovascular endocrinology | ECE2015

Anti-obesity effect of Aster spathulifolius Maxim extract

Cho In-Jin , Choung Se Young , Kim Do Un , Hwang You-Cheol , Ahn Kyu Jeung , Chung Ho Yeon , Jeong In-Kyung

Purpose: Aster spathulifolius Maxim is one of plants of chrysanthemum, which has shown an anti-obesity activity in diet induced mice model. We performed clinical trial for evaluating the anti-obesity efficacy and safety of Aster spathulifolius Maxim extract on obese human.Methods: This study was randomised, double-blind, placebo-controlled clinical trial in Korea. A total of 41 obese subjects (BMI 25–30 kg/m2) aged ≥20 years were ra...