Searchable abstracts of presentations at key conferences in endocrinology

ea0077lb26 | Late Breaking | SFEBES2021

A microfluidics approach of mimicking an obese maternal metabolic environment identifies modified pathways in the endometrial epithelium that may be important for implantation

Tinning Haidee , Baik Soo Young , de Vasconcelos Elton , Forde Niamh

Women who are obese are more likely to suffer early pregnancy loss. Once factor that can contribute to this is endometrial dysfunction however, we are limited in our understanding of how stressors or treatments, may alter endometrial function. Mimicking the dynamic in vivo exposure of the endometrium to these stressors is difficult using in vitro static culture systems. The aim of this study was to use a microfluidic approach to mimic exposure of the endometr...

ea0078oc4.5 | Oral Communications 4 | BSPED2021

The biochemical evaluation of Metabolic Bone Disease of Prematurity (MBDP) in a high-risk population

Watts Gemma , Young Aneurin , Johnson Mark John , Chowdhury Olie

Background: MBDP describes inadequate mineralisation of bones in the preterm infant. Traditionally, neonatologists have used a raised ALP and low phosphate to diagnose MBDP, with phosphate supplements as first-line treatment. An alternative management approach, published by Chinoy et al (2019), recommended PTH and vitamin D in the routine work-up. Objectives: We undertook a review of data across two neonatal intensive care units:<p class="ab...

ea0090ep911 | Reproductive and Developmental Endocrinology | ECE2023

Position and Characteristics of adolescents diagnosed as PCOS under the original Rotterdam criteria but excluded under the 2018 updated guideline

Kim Jinju , Ri Hwang Kyu , Kim Sunmie , Min Choi Young

Background and Aims: Polycystic ovary syndrome (PCOS) usually develop symptoms during adolescence. However, diagnosis in adolescents is challenging because physiologic development overlap typical manifestation of PCOS. Recently, an international evidence-based PCOS guideline development group recommended that ultrasound should not be used for the diagnosis of PCOS in those with a gynecological age of < 8 years. Thus, girls with irregular menstruation (IM)/PCO or hyperandro...

ea0090ep919 | Reproductive and Developmental Endocrinology | ECE2023

Serum AMH in women with polycystic ovary syndrome

Kim Jinju , Ri Hwang Kyu , Kim Sunmie , Min Choi Young

Background and Aims: Anti-Müllerian hormone (AMH) is secreted by granulosa cells of ovarian follicles. Since AMH reflects the number of antral follicles and the pronounced androgen secretion from follicles/stroma in women with polycystic ovary syndrome (PCOS) remains until late reproductive age, the age related relationship between AMH in women with PCOS are of interest. Methods: Women with PCOS (aged 15–42 years) (n=537) participated ...

ea0065p167 | Metabolism and Obesity | SFEBES2019

Sarcopenic phenotypes are associated with an increased risk of type 2 diabetes: findings from the Korean Genome and Epidemiology Study (KoGES)

Son Jang Won , Lee Won Young , Yoo Soon Jib

The present study aimed to explore the relationship of sarcopenia, with or without the presence of obesity, with the risk of developing type 2 diabetes. We conducted a cross-sectional analysis of 2981 subjects in the Korean Genome and Epidemiology Study. The diabetes status of each subject was determined by using a 75 g oral glucose tolerance test, and body composition was estimated via dual-energy X-ray absorptiometry. The skeletal muscle mass index (SMI, %) was obtained by c...

ea0049ep211 | Bone &amp; Osteoporosis | ECE2017

Bisphosphonate related osteonecrosis of the jaw: risk factors: a case report

Young Pablo , Elias Natalia , Rella Noelia , Moran Marcela , Curria Marina

Introduction: Bisphosphonates (BP) have been employed for many years and have demonstrated an excellent safety profile. Nevertheless, severe osteonecrosis of the jaw (ONJ) have been described in patients with bone metastases that were treated with BP for many years.Case: A 72 year old female with breast cancer and bone metastases treated with quadrantectomy, axillary lymph node dissection, radiotherapy, tamoxifen and pamidronate 90 mg/month. Two years la...

ea0037ep645 | Obesity and cardiovascular endocrinology | ECE2015

Time-of-day-dependent rhythms in the transcriptional responsiveness of the rat heart to triiodothyronine

Peliciari-Garcia Rodrigo , Previde Rafael , Young Martin , Nunes Maria Tereza

Myocardial gene expression and metabolism fluctuate over the course of the day, in association with changes in energy supply and demand. Recently, time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of cardiac form and function. The genomic actions of T3 are triggered after its interaction with thyroid hormone nuclear receptors that ofte...

ea0035p114 | Calcium and Vitamin D metabolism | ECE2014

A novel mutation in GATA3 gene in HDR syndrome

Kim Doo-Man , Yang Seung , Park Juri , Son Ho Young

The combination of hypoparathyroidism, sensorineural deafness and renal dysplasia, named HDR syndrome, is a rare disease. Heterozygous abnormalities of GATA3 gene are associated with this syndrome. Here we report a novel heterozygous mutation, c.255_256ins4 (GTGC), in GATA3 gene. A 41-year-old man was diagnosed as having idiopathic hypoparathyroidism and has been treated with 1α-hydroxyvitamin D3 and calcium carbonate. Three years later, he had a hearing...

ea0070aep1069 | Hot topics (including COVID-19) | ECE2020

The role of growth hormone device optimisation in patient-reported outcomes: Real-world evidence from South Korea

Lee Ji-Eun , Lee Kee-Hyoung , Park Mi Jung , Yang Seung , Young Kim Eun , Rhie Young-Jun , Jung Min-Ho , Yang Aram , Kim Shin-Hye , Yoojin Chung Lindsey , Young Ko Su , Ju Lee Young , Nedjatian Navid , Yeong Chung Woo

Growth hormone (GH) therapy (GHT) requires long-term commitment to daily sc GH injections that may present adherence challenges. Patient preference and adherence have been shown to be affected by delivery devices in association with convenience of administration, level of injection-site pain, confidence in correct dose administration and satisfaction with the device. This survey investigated if switching GH device – from NordiLet/others to NordiFlex – improved pati...

ea0032p616 | Female reproduction | ECE2013

Menstrual cycle length is associated with metabolic syndrome in young Korean women with oligomenorrhea

Oh Jee-Young , Sung Yeon-Ah , Lee Hye Jin

Introduction: Although menstrual irregularity, including oligomenorrhea (OM), is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with OM is unclear. We evaluated whether a longer menstrual cycle length is associated with less favorable metabolic features in young women.Methods/design: A total of 1296 young women (aged 15–39 years old) with ...