Endocrine Abstracts

In supine subjects aldosterone daily variations are determined by spontaneous PRA rhythmicity and ACTH secretory bursts. The aim of this study was to analyze diurnal and pulsatile aldosterone secretion in two patients with primary aldosteronism (PA): a 33-year-old woman with aldosterone producing adenoma (APA) and a 40-year-old woman with idiopathic adrenal hyperplasia (IAH). Blood samples were taken hourly during 24 hours at the time of the diagnosis and three months later, a...

Adrenal incidentalomas are incidentally discovered adrenal tumors by imaging methods without any prior suspicions of adrenal disease. Most of these tumors are functionally inactive but thorough investigations can reveal discrete hormone excess. Chromogranin A(CgA) is expressed in neuroendocrine cells throughout the body, including large and small intestine, adrenal medulla and pancreatic islets. It is a marker for carcinoid tumors, paragangliomas, and other neuroendocrine tumo...

In this study we wanted to assess whether affective changes influence cortisol response during low dose (1 microgram) ACTH test. Beck Inventory of Depression and Hamilton Anxiety Rating Scale and low dose ACTH test were performed in five subjects during the prolonged psychological stress induced by war and 18 months later. After the war, Beck Inventory of Depression and Hamilton Anxiety Rating Scale scores were significantly reduced. Suppression of the HPA axis was present dur...

Most macroprolactinomas are responsive to dopamine against drugs. Bromocriptine (BRC) has been available and extensively used in our country. The aims are to assess the outcome in 29 patients with macroprolactinomas who were treated with BRC.Material and methods: A multicentric study of 29 patients with macroprolactinoma (19 female; 10 males). The mean age was 33 years. The pituitary mass was larger than 10 mm in diameter. There was no endocrinological e...

Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogensm in women under 40 years. Sex steroids play an important role in maintaining bone mass and cessation of ovarian function results in significant bone loss.Objective: To evaluate bone mass density (BMD) and factors influencing it in women with POF.Design & methods: First group of 144 women with spontaneous POF (I), 39.7±7.6 y...

Increased dietary intake of polyunsaturated fatty acids (PUFAs) has been reported to be associated with a decreased incidence of cardiovascular disease. Increased dietary intake of polyunsaturated fatty acids (PUFAs) has been reported to be associated with a decreased incidence of cardiovascular disease. We have recently reported that ovarian steroid synthesis in ewes fed a diet high in n-3 PUFAs is significantly compromised1. Hence in this study we have assessed th...

Background: Although it is well known that glucocorticosteroids induce insulin resistance, probably due to postreceptor defects, the exact time scale is still a matter of debate.Objective: The aim of the present study was to determine the time scale of effects of therapeutic doses of glucocorticoids on insulin sensitivity.Methods: Study group consisted of 20 patients with Graves ophtalmopathy who were treated with corticosteroids f...

Aim: Evaluation of efficacy and safety of thyroid artery embolization procedure as a method of treatment of hyperthyreosis.Patient and methods: Since May 2004 to July 2005 the thyroid artery embolization procedures have been performed in 9 pts (7 women and 2 men) in mean age 62.3 (44 – 77). The reason for such a treatment were: hyperthyroid goiter with the other organs compression in 5 cases, Graves disease in 2 and thyrotoxicosis type I after amiod...

Introduce: Lack of radioiodine uptake in Differentiated Thyroid Carcinoma (DTC) is a huge diagnostic and therapeutic problem. This sign is associated with worse prognosis. In patients with elevated thyroglobulin levels and with no evidence of disease on radioiodine scintigraphy, scintigraphy with somatostatin analogs can be an alternative imaging modality.The aim: Assessment of scintigraphy with the somatostatin analog 99mTc-HYNIC-TATE to visu...

Introduction: An increase of thyroid iodine uptake (Tup) is one of the symptoms of thyrocyte stimulation by means of recombinant human thyrotropin (rhTSH). Low Tup, characteristic of iodine induced hyperthyroidism, creates serious problems, when 131I is considered, making this kind of treatment difficult, if not impossible.Material and methods: We report a case of a 74 years old patient, with hyperthyroidism, induced by amiodarone administrati...