Searchable abstracts of presentations at key conferences in endocrinology

ea0011p473 | Endocrine tumours and neoplasia | ECE2006

WNT4 expression in normal human adrenals and adrenocortical tumours

Kuulasmaa T , Jääskeläinen J , Pietiläinen T , Loimas S , Aaltomaa S , Heikkilä P , Kosma V-M , Voutilainen R

Members of the secreted WNT glycoprotein family are important in embryogenesis and adult tissue homeostasis, and defects in the signal transduction of several WNT ligands including WNT4 have been linked to a variety of clinical conditions. Deletion of Wnt4 gene in mice leads to improper development of many organs including the adrenals in which the zona glomerulosa forms imperfectly. The objective of this study was to investigate the expression of WNT4 in human adult and fetal...