Endocrine Abstracts

Introduction: Thyroid nodules are common and are often found incidentally by palpation. Most of thyroid nodules are benign but 0–10% are malignant. A small proportion are due to metastatic lesions from other primary tumors. FNA is a standard diagnostic procedure to differentiate between benign and malignant nodules. But the use of additional immunochemistry markers will be important for diagnosis.Lung adenocarcinoma is one of the tumors which may me...

Metabolic syndrome is a clustering of several cardiovascular risk factors including obesity, hypertension, diabetes, high triglyceride etc. Obesity has been shown to decreases key markers of uterine contractility during parturition in the rat and diabetes is associated with impairment of uterine contractility and high caesarean section rate. In this study, the effect of metabolic syndrome on gravid uterine muscle contractility in sprague-dawley rat was deter...

Metabolic syndrome is a clustering of several cardiovascular risk factors including obesity, hypertension, diabetes, high triglyceride etc. Obesity has been shown to decreases key markers of uterine contractility during parturition in the rat and diabetes is associated with impairment of uterine contractility and high caesarean section rate. In this study, the effect of metabolic syndrome on gravid uterine muscle contractility in sprague-dawley rat was deter...

Background: Pubertal induction with incremental doses of oestrogen replacement is an important component of care offered to hypogonadal patients with Turner Syndrome (TS). Low dose oral ethinylestradiol (EE) has been extensively used in the UK but natural 17-β oestradiol (more physiological, cheaper and easily monitored in blood) is becoming increasingly popular. We undertook this audit to compare the efficacy and acceptability of oral (EE) and patch (Evorel) oestrogen pr...

Background: Turner syndrome (TS) is characterised by a wide phenotype and age at presentation. We reviewed our over-12s Turner clinic over a period of 10 years to evaluate pattern of diagnosis, co-morbidities and management.Subjects and method: Retrospective data analysis of patients with TS who attended the over-12s clinic (2008–2017, n=28). Data is median (IQR) or mean±SD as appropriate.Result: The age at diagn...

Diabetes mellitus (DM) is a disease of epidemic proportions. Most of DM patients are classified as type 2 diabetes mellitus (T2DM) that is linked with resistance to insulin action on target tissues. In 2015, 415 million people were living with DM worldwide with the highest prevalence rates recorded in the Oceania and the Middle East and North Africa (MENA) regions. In Jordan, a MENA country, the prevalence of DM has increased from 13% to 17% over a 10-year period (1994–20...

Pituitary neuroendocrine tumours (PitNETs) are heterogeneous and have limited biomarkers to predict their behaviour, thus making their prognostication difficult. Ki-67 is a protein expressed in active phases of the cell cycle and is one of the biomarkers utilized in routine assessment of PitNET tissue. Current European Society of Endocrinology recommendations advise that histopathological analysis of PitNETs should as a minimum include Ki-67 proliferation index and anterior pi...

Objectives: 1) When and how to investigate rarer causes of short stature. 2) Evidence for interventions to improve growth in metaphyseal chondrodysplasia, Schmid-type (MCDS).Background: The incidence of skeletal dysplasia is one in 5000, however individually these conditions are rare and prognosis unclear. There is genotypic and phenotypic heterogeneity and no current consensus on classification, which may include clinical, radiographic, molecular or his...

Introduction: Over the last decade there has been a steady rise in obesity and co-morbidity, but little is known about the rate of metabolic dysfunction among young adults in the United Arab Emirates. Various factors have been implicated as biomarkers of metabolic syndrome (MetS). The objective of this study was to analyze the relationships of various biomarkers (leptin, C-reactive protein (CRP), adiponectin, insulin, and uric acid) to the MetS components in lean, overweight, ...

Objective: To evaluate pheochromocytoma that occurs in Saudi patients with MEN 2APatients and methods: Of 44 patients belonging to 5 MEN 2A families, 14 (31.8%) presented with pheochromocytoma. The following variables have been studied: clinical and diagnostic data (age, mutation, clinical features, and laboratory studies included measurements of 24-h urinary catecholamines, epinephrine, metanephrine, norepinephrine, dopamine, vanillylmandelic acid, and ...