Endocrine Abstracts

Introduction: Cytological diagnostics has got an established position in thyroid diseases. In the recent years, attempts have been undertaken to use the biological material, left in needles after cytological preparation is ready, to obtain additional diagnostic data.Goal of study: The goal of the study was evaluation of the possibility to use the results of fine-needle aspiration biopsy (FNAB) for confirmation of either the presence or the absence of lym...

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

Introduction: Dendritic cells (DCs) are considered as main regulators of immune system. Functional properties of DCs depend on their subtype, maturation status, interaction with other immune cells as well as environmental factors including hormones. Recently, we have shown a direct, independent of TSH, regulatory influence of thyroid hormones on human DCs function. The aim of the present study was to analyze ex vivo the effect of systemically administered TSH on human...

Objective: The presence of a single parathyroid adenoma is a cause of primary hyperparathyroidism in most cases. Minimally invasive parathyreoidectomy is a treatment of choice in PHPT patients and precise localization of the changed parathyroids is crucial for successful removal.The aim of the study was to assess usefulness of parathormone level estimation in the material obtained during FNAB of the focal neck lesions in order to differentiate structures...

The effectiveness of thyroid remnants ablation with 131I after thyroidectomy for differentiated thyroid carcinoma (DTC) depends mainly on absorbed radiation dose, which is proportional to 131I uptake (Tup) and its effective half-life time (EHL) in the remnants.Aim: Assessment of endogenous TSH level increment effects on EHL of 131I and Tup in thyroid remnants after surgery for DTC.Material: Twenty-o...

IntroductionDiagnostics of thyroid dysfunctions is frequently based on the measurements of TSH serum concentration only. Currently, due to a tendency to minimize stressful situations for a child (such as venipuncture to take a blood sample), some tests (i.e. TSH assessment) are performed at the Primary Healthcare Centre while other diagnostic tests (e.g. during an infection) are run. If TSH serum concentration is outside the reference range, it leads to ...

Sclerostin, a product of a SOST gene, is a protein expressed by osteocytes that inhibits osteoblastic bone formation. Several hormones including PTH and glucocorticosteroids and have been suggested as possible regulators of sclerostin production. The influence of thyroid hormones on sclerostin synthesis has not been investigated so far. The aim of the study was to evaluate sclerostin concentrations in patients before and after treatment of thyrotoxicosis.<p class="abstext"...

Goiter prevalence (GP) and median UIC in population studies are both considered markers of iodine nutrition. Controversy exists which of them is more reliable.Aim: To assess correlation between UIC and thyroid volume in Polish schoolchildren.Material and methods: 9402 Polish schoolchildren (51.3% girls, 48.7% boys) aged 6–12 years were examined in 1999–2011 (‘Thyromobil’ action). 40.9% of children were born at l...

Objective: Aiming at the highest specifity in differentiating benign from malignant thyroid nodules effects in new diagnostics developments. Recent technologies such as elastography enable determination of tissue stiffness difference between focal lesions and surrounding thyroid tissue – reference tissue. This method is based on quantifying the stiffness of the lesion – the malignant changes show decreased elasticity when compared to adjacent tissue. Tissue Doppler u...