Endocrine Abstracts

The majority of differentiated thyroid cancer (DTC) cases will be successfully treated with surgery usually (but not always) followed by radioiodine (RAI). The large majority have excellent prognosis. 10% of DTC may present disease progression: local relapse and/or distant metastases. 25–50% of these will slowly loose the capacity to take up radioiodine – RAI refractory cases. Further management includes loco-regional therapies such as surgical excision of lesions ca...

Thyroid cancer (DTC) is diagnosed more frequently these days due to increased awareness, wider availability of detection tools and, possibly, to true increasing incidence. The epidemiology of DTC is thus changing and more ‘innocent’ tumours are now being detected. The management of thyroid cancer and nodules is evolving and much progress has recently been made in the diagnosis and follow-up. Management guidelines have recently been published by scientific bodies and ...

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...

Objectives: Patients suffering from pulmonary or/and neoplastic disease are at higher risk of developing serious illness from SARS-CoV-2. TC patients with lung metastases are classified as high-risk for severe CoV-2 disease. Aim of this study was to investigate SARS-CoV-2 prevalence and severity in this particular subgroup of patients.Methods: Out of 28 patients with metastatic Differentiated Thyroid Cancer (DTC) and 21 patients with met...

Objectives: Coexistence of two different malignancies is frequently reported. Sometimes occurs in the context of well-established syndromes like MEN2. Rearranged during transfection (RET), is an oncogenic driver activated in different kinds of neoplasias such as: MTC, Differentiated Thyroid Cancer (DTC), Non-Small Cell Lung Cancer (NSCLC). We have previously reported an increased prevalence of DTC in familial MTC patients carrying the RET (G533C) mutation. Ai...

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1: a 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed followed by neck diss...

Objectives: DTC has a favorable clinical course. A small percentage of patients undergoing surgery and RAI ablation may have local disease persistence and further therapeutic interventions may be needed such as further RAI administration following or not a second surgery. We investigated whether additional therapeutic interventions may be beneficial for the clinical course in DTC patients with disease persistence.Methods: 812 DTC patients (men 25.7%, age...

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1A 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed...

Objectives: Distant metastases in MTC adversely affect disease prognosis. Somatic mutations in spMTC as well as Variant Allele Frequency (VAF) have been related to tumor burden, disease course and the response to TKIs. The aim of this study is to report three cases of nucleotide (nt) insertions/deletions (indels) in the RET oncogene in relation to disease course/response to TKIs.Methods: Of 195 spMTC patients followed-up in Dept. Clinical Therap...

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...