Searchable abstracts of presentations at key conferences in endocrinology

ea0032p188 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

A potential predict value of circulating osteoprotegerin in diabetic patients with asymptomatic coronary artery disease

Berezin Alexander , Kremzer Alexander

Background: Osteoprotegerin (OPG) is a bone-related glycopeptide produced by vascular smooth muscle cells due to arterial damage. OPG is considered as an independent predictor of cardiovascular disease in diabetic populations.The aim of this study was to evaluate the interrelation between circulating OPG and coronary vasculature damage in type 2 diabetes mellitus patients.Methods: One hundred and twenty six subjects with stable dia...

ea0032p404 | Diabetes | ECE2013

Circulating endothelial progenitor cells as a predictor of clinical outcomes in diabetic patients with symptomatic chronic heart failure

Berezin Alexander , Kremzer Alexander

Background: Recent evidence has defined that circulating endothelial progenitor cells (EPCs) might have a pivotal role in the presence of atherosclerosis, chronically diseased vessels or following acute vascular injury. We hypothesized that diabetes mellitus (DM) may be related to worsening of ischemic chronic heart failure thereby suppression of mobilization of bone marrow-derived EPCs.The aim of this study was to evaluate predict value of circulating E...

ea0050s7.3 | Taking a risk on love - the endocrinology of behaviour | SFEBES2017

Kisspeptin and the control of reproductive behaviour

Comninos Alexander

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

ea0050s7.3 | Taking a risk on love - the endocrinology of behaviour | SFEBES2017

Kisspeptin and the control of reproductive behaviour

Comninos Alexander

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

ea0063ep127 | Reproductive Endocrinology | ECE2019

The role of transcription factors in control of ovarian functions

Sirotkin Alexander

We are the first who studied the control and the role of transcription factors in the regulation of reproductive functions. Our presentation represents a short review of original data concerning external (temperature, calories restriction) and internal (hormones, protein kinases, RNA interference) in control of selected transcription factors (p53, NFkB, STAT1, CREB1), as well as their role in control of basic ovarian cell functions (proliferation, apoptosis, secretory activity...

ea0041s1.1 | Thyroid and Pregnancy | ECE2016

At which TSH cut-off should we start LT4 therapy during pregnancy

Alexander Erik

Hypothyroidism in pregnancy is generally considered harmful. However, the definition of hypothyroid during pregnancy remains controversial. Measurements of maternal serum TSH have traditionally been used to define hypothyroidism, with values >2.5 mIU/l generally warranting treatment. However, recent data have suggested that the ‘normal’ reference range for serum TSH in healthy pregnant women varies by region as well as by ethnicity. Importantly, changing the uppe...

ea0035p628 | Female reproduction | ECE2014

New endocrine and intracellular regulators of reproductive functions

Sirotkin Alexander

Progress in reproductive medicine, assisted reproduction, veterinary medicine and animal production and biotechnology is promoted by discovery and application of the new extra- and intracellular regulators of reproductive functions. This is the review of original data concerning the role of some metabolic hormones (GH, leptin, ghrelin and obestatin), growth factors (IGF1, IGFBPs, EGF and thrombopoietin), intracellular mediators of their action (cyclic nucleotides, protein kina...

ea0022s6.1 | Neuroendocrine control of reproduction | ECE2010

Sexual differentiation of hypothalamic Kiss1 neurons

Kauffman Alexander

The status of the neuroendocrine reproductive axis differs between various stages of development and adulthood, and also differs between the sexes, including earlier onset of sexual maturation in females than males and the ability to generate a preovulatory gonadotropin surge in adult females but not adult males. The reproductive axis is controlled by various hormonal and neural pathways that converge upon forebrain GnRH neurons, and many of the developmental and sex differenc...

ea0021p306 | Reproduction | SFEBES2009

Direct control of ovarian functions by ghrelin

Sirotkin Alexander

The recent original data concerning interrelationships between ghrelin and feeding, action of ghrelin on ovarian functions (proliferation, apoptosis, secretory activity, response to gonadotropins, oocyte maturation) and intracellular mechanisms of its action in different species (rabbit, pig, human, chicken) are reviewed. It was shown, that ghrelin can control proliferation, apoptosis, suppress release of ovarian hormones and inhibit response of ovarian cells to gonadotropin, ...

ea0004ds10 | Impotence | SFE2002

HOW TO TREAT: A DIABETOLOGIST'S VIEW

Alexander W

Erectile failure is a common yet often neglected complication of diabetes that may have a significant negative effect on quality of life and diabetes self-care. I would initially try to ensure a good ascertainment rate of the problem in men attending the diabetes service. I would encourage, though usually fail to persuade men to attend with their partners. I would ascertain the exact nature of the problem, the likely cause, the importance of the problem to the man, the nature ...