Endocrine Abstracts

Exercise induces an increase in cardiac output, respiration and fuel mobilisation. Whilst the cardio-respiratory response to exercise is similar in type 1 diabetes to that seen in non-diabetic individuals, the response to mobilisation of fuel source to support exercise is impaired.Normally when exercising changes in insulin and counterregulatory hormones secretion are made which are dependent on the type of exercise being performed. These changes facilit...

Current evidence suggests that bariatric surgery offers the best hope for substantial and sustainable weight loss in patients with morbid obesity. These facts, coupled with the improved minimally invasive procedures, have driven a four-fold increase in the number of bariatric operations performed over recent years in the UK.Bariatric surgery though is not suitable for everyone. A BMI>59, Age>50, smoking, sleep apnoea and CVD disease all increase ...

Overeating and decreased activity are the fundamental problems underlying the development of obesity, thus any therapy aimed at helping the obese patient must have a dietary and exercise component.In general three forms of lifestyle interventions are used; exercise, diet and behavioural therapy. Exercise alone produces an average weight loss of 1.8 kg (0–4 kg) with a higher intensity of exercise leading to a greater weight loss. Diastolic blood pres...

Postprandial Hyperinsulinaemic Hypoglycaemia reportedly occurs in 0.1 to 0.3% of patients after Roux-en-Y Bypass procedures. In our Bariatric Surgery Service we seem to be seeing this complication more frequently. Most patients can be managed in a step-wise approach, but we have a few patients who appear refractory to conventional treatment. This case illustrates one such patient. Mrs P was referred to the Weight Management service in 2011, aged 45. She weighed 108 kg, with a ...

Background: Diabetes increases the risk of developing coronary heart disease irrespective of glycaemic control. Cortisol and growth hormone (GH) abnormalities have been found in these patients and have been proposed as possible mechanisms for this increased risk.Regular exercise, through an unknown mechanism, can modify cardiovascular risk and so prevent or delay the progression of coronary heart disease. In this study we assessed whether an exercise program would a...

Andrew Hattersley, Peninsula Medical School, Plymouth, UK AbstractAndrew Hattersley qualified from Oxford in 1984. He trained in Diabetes at the Hammersmith Hospital, Oxford and Birmingham before taking up his present post as a consultant Diabetologist in Exeter in 1995.His principal area of research is the molecular genetics of diabetes with a particular emphasis on monogenic diabetes. He has ta...

Mrs MP was referred to the Weight Management service in 2011, aged 45. She weighed 108 kg, with a BMI of 40 kg/m2. She had type 2 diabetes, but no other past medical history and was working in a high profile job. A Roux-en-Y bypass was performed in November 2011, with no immediate complications. She successfully lost 25% of her body weight and by April 2012 weighed 79.2 kg. Towards the end of 2015 she was re-referred with symptoms of severe fatigue, poor concentrati...

BackgroundIndividuals who do day/night shifts or who are exposed to 24 hours of daylight have a greater CVS risk. This may relate to effects on the diurnal rhythm of sleep, appetite or cortisol.AimsTo investigate the variations in the diurnal cortisol secretion, appetite and sleep in young healthy civilians from the UK during a five week expedition to Svalbard in the Arctic with 24 hours of daylight.<p cl...

Background: Telemedicine use has increased rapidly during the COVID-19 pandemic, replacing many face-to-face (FTF) consultations. FTF consultations are associated with increased CO2 emissions (CO2em) from travel to clinics. This study evaluates the triple bottom line of children and young people’s (CYP) and parent or guardian experience of a new telemedicine service, estimated CO2em saving from reduced travel and cost saving to families.Methods: Dat...

Background: Growth Hormone Insensitivity (GHI) is characterised by short stature and functional IGF-I deficiency associated with normal/elevated GH levels. Marked genetic and phenotypic heterogeneity exist, and heritable defects in GH-IGF-I axis associated pathways account for mild-moderate to severe GHI. We report non-consanguineous twin brothers who present with short stature and bi-allelic mutations in QSOX2 encoding a nuclear membrane protein. Genome-wide associat...