Endocrine Abstracts

Graves’ disease (GD) and myasthenia gravis (MG) may be associated and influence one another clinical expression. We report the cases of 3 female patients who presented this particular association. First patient (RL, 55 years), was diagnosed with MG and, 5 years after, developed GD, remitted after 2 years of anti-thyroid drugs (ATD). She is still euthyroid after more than 10 years, and MG is compensated with moderate doses of anticholinesterase drugs (ACD). Thoracic CT sho...

Magnesium (Mg), the second most abundant intracellular cation of the human body, plays a crucial role in nerve and muscle function. Although a frequent electrolyte abnormality, hypomagnesaemia is one of the most underdiagnosed one, symptoms being present only when Mg levels decrease bellow 0.5 mmol/l, Among the various causes of Mg deficiency endocrine disorders are neither the most frequent nor the most studied. An exception is the implication of Mg in bone and calcium metabo...

Parathyroid carcinoma (PC) is a rare endocrine tumor accounting for 0.5–6% or less in cases of primary hyperparathyroidism. According to The American Joint Committee on Cancer (AJCC) eighth edition, the histopathological criteria for PC include the presence of vascular invasion with capsular invasion and progression and/or metastasis to adjacent tissues. However, the small number of cases of PC makes it difficult to predict prognosis in the postoperative period of PC. We ...

The critical problem of thyroid nodules is to identify the malignant ones Fine needle aspiration biopsy (FNAB) plays a crucial role in this diagnosis and enables the number of surgical operations to be reduced. We have evaluated the performances of FNAB in comparison with the histological examination in 1971 consecutive patients who suffered both fine-needle puncture and surgery in a 5 years interval at a University Hospital. FNAB was malignant or suspicious in 8.4% patients, ...

Medullary thyroid carcinoma (MTC) is a rare tumoral entity related to parafollicular C cells of the thyroid gland, characterized by peculiar morphological, functional and evolutional features. The aim of this study was to characterize the cases of medullary carcinoma diagnosed in a university hospital in a 5 years interval (January 1999–December 2003) and to evaluate the diagnostic methods. In this time interval, from a total of 171 thyroid malignancy, 12 (7%) were medull...