Endocrine Abstracts

Thyroid hormones exert their effects by stimulation of thyroid hormone receptors that have different tissue distribution and metabolic targets. TRβ is predominant in liver and mainly responsible for effects on cholesterol and lipoprotein metabolism, whereas TRα is most important in fat, muscle and heart. Thyroid hormone analogs (thyromimetics, tiromes) have been developed that activate TRβ are selectively taken up and/or activated by the liver. Such compounds st...

The placenta is a highly specialized organ, which ensures nutrient uptake, waste elimination, provides thermo-regulation, prevents passage of some xenobiotic molecules and regulates the quantity of thyroid hormones (TH) necessary for the fetal development. It is known, that even minor changes in maternal TH levels, can alter the fetal growth. Several factors can modify TH levels during pregnancy. Among them, increasing evidences show that prenatal exposure to persistent organi...

A 48-year - old woman was admitted in september 2015 for Cushing clinical sings obesity, weight was 120 kg, BMI 44,4 kg/m2, arterial hypertension 160/120 mmHg, hyperlipidemia, moon face, purplish abdominal strie, amenorrhoea, marked swelling of bouth lags, more right leg with varices. Because high D dimer and factor VIII there was suspicion of deep venous thrombosis, Doppler of veins was done immediately wich excludes deep vein thrombosis, and as part of preoperativ...

Objective: To learn characteristics of biochemical markers of bone metabolism, parameters of bone mineral density (BMD) and fat component of body composition for early diagnosis of bone disorders in children with primary nephrotic syndrome (NS).Material and methods: We compared data of laboratory investigations (phosphorus (P), total calcium (Ca), parathyroid hormone (PTH), and alkaline phosphatase (ALP)), protocols of dual-energy X-ray absorbtiometry of...

Diabetes mellitus disturbs cellular metabolism of all organs and systems, including myocardium. The disturbances in cardiomyocytes lead to changes of QT and QTc intervals prolongation. Research: to evaluate values of intervals QT and QTc in children with diabetes mellitus type 1 (DM1) and to reveal interrelation of the given changes with the duration of disease, age, sex, indices of metabolic control.Materials and methods: QT and QTc were evaluated on EC...

The basic manifestations of dystrophic changes in heart of children suffering form diabetes mellitus type 1 (DM1) are disturbances of repolarization and depolarization processes, including QT and QTc intervals prolongation. Research objective: to evaluate indices of QT and QTc in children with DM1, to reveal interrelation of the observed changes with the duration of disease, age, sex, levels of cholesterol (CH) and glycemie, BMI, blood pressure, pulse rate.<p class="abstex...

The basic manifestations of dystrophic changes in heart of children suffering from diabetes mellitus type 1 (DM1) are disturbances of repolarization and depolarization processes, including QT and QTc intervals prolongation. Research objective: to evaluate indices of QT and QTc in children with DM1, to reveal interrelation of the given changes with the duration of disease, age, sex, levels of cholesterol (CH), of glycemie, BMI, blood pressure, pulse rate....

Pancreatic neuroendocrine tumors (NET) have always represented a complex dilemma for diagnostic imaging. This is mainly due to their small size and brought during the years to a complex range of diagnostic proposals. A correct preoperative detection and staging are mandatory in order to choose management options and to optimize surgical treatment. Endoscopic Ultrasound (EUS) has been claimed to be the best technique for imaging the pancreas, it allows.Hi...

Obese subjects have lower risk for osteoporosis than normal weight people. Body mass index over 33 kg/m2 is associated with lowest risk for hip fracture in both sexes.Aim: Investigate overweight influence on bone mineral density of hip bone and lumbar spine in overweight postmenopausal women.Material and methods: Postmenopausal women N=100, without co-morbidity, 48–88 years of age, divided in two groups: grou...

A. Background/Significance: Autoimmune polyglandular syndrome Type II (APS-II) is a rare polyendocrinopathy with a prevalence of 1 to 2 in 100.000, instigated by immune-mediated destruction of several organs. Knowledge of APS-II is crucial, especially in the early detection of polyglandular disorder among patients with endocrine autoimmunity. B. Case: This case is of a 40-year-old male who initially presented with Grave′s disease after showing sign...