Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep79 | Bone and Calcium | ECE2020

Hypocalcemia due to pseudohypoparathyroidism diagnosed in adulthood

Antich Barceló Carlos

Introduction: Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of rare metabolic diseases, all characterized by end-organ resistance to the action of different hormones, primarily PTH. Main clinical characteristics are hypocalcemia and hyperphosphoremia associated with elevated parathyroid hormone (PTH) levels, frequently encompassing additional heterogeneous features, known as Albright’s hereditary osteodystrophy. A molecular cause can be identified in 80&...

ea0022p519 | Male reproduction | ECE2010

Exogenous gangliosides modulate cellular free radical production

Gavella Mirjana , Lipovac Vaskresenija , Antica Mariastefania , Garaj-Vrhovac Verica

Recent studies have reported that gangliosides, the sialic acid containing glycosphingolipids, are able to modulate many cellular functions. As reactive oxygen species (ROS) in human semen originate from both spermatozoa and infiltrating leukocytes, we aimed to investigate i) the ability of gangliosides to protect human spermatozoa from hydrogen peroxide (H2O2)-induced DNA and membrane damage and ii) the effect of gangliosides on the production of ROS by ...

ea0063p269 | Pituitary and Neuroendocrinology 1 | ECE2019

Diabetes insipidus and diabetes mellitus type 2 diagnosed at the same time in a male with langerhans cell histiocytosis

Barcelo Carlos Antich , Soler Guillermo Serra , Font Mercedes Noval , Ribas Elena Mena , Povidano Santiago Tofe , Jimenez Inaki Arguelles , Fernandez Honorato Garcia , Macazaga Vicente Pereg

Introduction: Langerhans cell histiocytosis (LCH) is a rare systemic disease. Diabetes insipidus is the most frequent endocrine alteration and occurs mostly after diagnosis. Others are hypogonadism, growth hormone deficiency (GHD) and alterations in glucose metabolism.Clinical case: A 61-year-old smoker, diagnosed with LCH 9 years ago with pulmonary and hepatic involvement, without treatment, who consulted for asthenia, unquantifiable polyuria, polydipsi...

ea0056p973 | Male Reproduction | ECE2018

Male hypogonadism due to 46, XX Testicular disorder of sex development

Font Mercedes Noval , Soler Guillermo Serra , Portilla Ana Jimenez , Barcelo Carlos Antich , Povedano Santiago Tofe , Ribas Elena Mena , Macazaga Vicente Pereg

Introduction: 46,XX testicular disorder of sex development (DSD) is a rare syndrome, which is characterized by a female karyotype in discordance with a male phenotype. It is presented with primary hypogonadism, gynecomastia and infertility. About 80–90% of 46,XX testicular DSD cases are positive for SRY gene. Appearance of external genitalia and masculinization are usually normal in 46,XX SRY-positive casesClinical case: A 41-year-old male came with...

ea0070aep60 | Adrenal and Cardiovascular Endocrinology | ECE2020

16 year-old woman with abdominal paraganglioma secondary to SDHB mutation

Bodoque Cubas Javier , Mena Ribas Elena , Serra Soler Guillermo , Antich Barceló Carlos , Argüelles Jiménez Iñaki , Tofé Povedano Santiago , Codina Marcet Mercedes , García Fernández Honorato , Pereg Macazaga Vicente

Introduction: Catecholamine-secreting tumours derived from the adrenal medulla and the nodes of the autonomic nervous system are known as pheochromocytomas or paragangliomas, respectively. Although their clinical manifestations are similar, their differentiation is important from an epidemiological and prognostic point of view and their possibility of being associated with genetic syndromes.Case report: We present a case of a 16 year old patient, with no...

ea0056p50 | Adrenal cortex (to include Cushing's) | ECE2018

Is the adrenal vein sampling the gold standard diagnostic test for the subtyping of primary aldosteronism?

Portilla Ana Jimenez , Ribas Elena Mena , Bennasar Antonia Barcelo , Ruitort Juan Manuel Martinez , Segurola Cristina Alvarez , Font Mercedes Noval , Barcelo Carlos Antich , Soler Guillermo Serra , Jimenez Inaki Arguelles , Povedano Santiago Tofe , Macazaga Vicente Pereg

Introduction: Primary aldosteronism (PA) is the most common cause of secondary hypertension (5–10%) and it is underdiagnosed. Less than 50% of patients with PA have hypokalemia. The tests for determinate subtype of PA are cross-sectional imaging (adrenal CT or MRI) and adrenal vein sampling (AVS). The AVS seems to be important to direct appropriate therapy and surgery is the preferred treatment for patients with unilateral disease.Material and metho...

ea0070aep758 | Pituitary and Neuroendocrinology | ECE2020

Silent corticotroph adenoma: Experience with six cases

Serra Soler Guillermo , Antich Barceló Carlos , Bodoque Cubas Javier , García Fernández Honorato , Mas Bonet Antonio , Antón Valentí Ester , Mena Ribas Elena , Tofé Povedano Santiago , Argüelles Jiménez Iñaki , Pereg Macazaga Vicente

Introduction: Silent corticotroph adenomas (SCA) represent a subtype of pituitary adenomas whose prevalence is 3% of pituitary adenomas. They are characterized by having a positive immunohistochemistry to corticotropin (ACTH) without clinical or biochemical data of hypercortisolism. The diagnosis is a challenge since they are considered as ANF, and it is with the pathology report after surgery when they are classified as SCA. They have more aggressive behavior and recur more t...