Endocrine Abstracts

In terms of mechanism by which thyroid diseases lead the endothelial dysfunction, several aspects have been taking into consideration. One potential factor may be variation in plasma asymmetric dimethylarginine (ADMA) levels. ADMA, which is derived from the catabolism of proteins containing methylated arginine residues, competitively inhibits NOS. The relationship between thyroid disease and variation in plasma ADMA levels is still a potential research area. The aim of this st...

Introduction: Hypoglycemia is defined as a reduction in plasma glucose concentration to a level that may induce symptoms such as sweating, shaking, palpitation, headache, blurry vision, loss of consciousness, seizure, coma. We present a case with hypoglycemia which is due to the use of exogenous insulin.Case presentation: A 72-years-old patient with Alzheimer disease who was admitted to the emergency clinic because of unconscio...

Introduction: U-300 glargine is a new generation long acting insulin. Nocturnal hypoglicemia and weight gain with U-300 glargine is lower than U-100 glargine. However, it may take 3–4 days for U-300 glargine to reach stable state in plasma. We report a diabetic case with recurrent ketosis after U-300 glargine.Case presentation: A 20 years old woman with type 1 diabetes mellitus who uses basal and bolus insulin (U-300 glargine and insülin aspart...

Introduction and aims: Polycystic ovary syndrome (PCOS) is a frequent endocrinopathy among with young women. It is known that insulin resistance is encountered in the vast majority of the women with PCOS and hence the risk of type 2 diabetes mellitus and coronary artery disease are increased. These cardiac and metabolic risk increments may also associated with hyperandrogenemia and dyslipidemia. The metabolic changes of lipid profiles in young women with PCOS are not completel...

Background and aim: Although insulinoma typically causes fasting hypoglycemia, postprandial hypoglycemia occasionally reported in these patients. We aimed to report a rare case of insulinoma who atmitted to outpatient clinic with postprandial hypoglycemia.Case report: A 31-year-old woman was admitted to outpatient clinic with postprandial hypoglycemia. Capillary blood glucose levels were found 25 and 27 mg /dl during typical hypoglycemic symptoms such as...

Introduction and aim: Cabergoline, a long-lasting dopamine-agonist, is generally considered to be the safety drug for the treatment of prolactinoma. But, use of long time and high dose cabergoline may be a cause of cardiac valvulopathy in patient with prolactinoma. In present study, we aim to determine serum N-terminal probrain natriuretic peptide levels in patients with prolactinoma who were treated with cabergoline.Materials and methods: Thirty patient...

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).Materials and method: Thirty-two women with PCOS (age: 23.4–4.6 years; BMI: 23.8–4.8 kg/m2), similar age and BMI have features 30 healthy womens c...

Introduction: Hyperthyroidism is associated with asymptomatic hypercalcaemia due to increased calcium mobilization from bone and catecholamine metabolism. Hypercalcaemia secondary to hyperthyroidism coexist with decreased or normal parathyroid hormone level. We reported case of 30-year-old man who suffered from Graves’ disease and primary hyperparathyroidism.Case report: A 30-year-old male patient was admitted to our hospital suffered from palpitati...

Introduction and aim: Congenital adrenal hyperplasia (CAH) is rare autosomal recessive disease. CAH due to 21-hydroxylase deficiency accounts for 95% of cases. We aim to define in this report 59-year-old woman with simple virilizing type CAH who diagnosed granulosa cell tumour and I172N mutation in the CYP21A as well as triple translocation involving chromosome 9p, 11p and 12p at first time in the literature.Case report: A 59-year-old woman was applied t...

Introduction and objective: Cardiovascular mortality is high in acromegaly. Our aim in this study was to determine the levels of the new cardiovascular marker in active acromegaly patients, the mean platelet volume (MPV) values before and after octreotide acetate long-acting repeatable treatment.Material and methods: Thirty-six patients with active acromegaly who presented at the Endocrinology Department (mean age 46.0±14.0 years and mean BMI: 30.4&...