Searchable abstracts of presentations at key conferences in endocrinology

ea0056p324 | Clinical case reports - Thyroid/Others | ECE2018

Dapagliflozin and Atkins Diet in a patient with type 2 Diabetes Mellitus: A combination that should be avoided

Grammatiki Maria , Rapti Eleni , Dina Despina , Koufakis Theocharis , Antonopoulou Vasiliki , Tsekmekidou Xanthippi , Yavropoulou Maria , Karras Spyridon , Zebekakis Pantelis , Kotsa Kalliopi

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

ea0048cb4 | Additional Cases | SFEEU2017

A calcium conundrum

Glyn Tessa , Atkins Marc

Mr RP is a 69 year old gentleman who presented to A&E following a fall. He described several weeks of lethargy, ataxia, confusion and polydipsia. He had a past medical history of hypertension and COPD, but was otherwise fit and well. On admission bloods revealed an adjusted calcium of 5.25, with a PTH of 2.4. He also had a significant AKI with an eGFR of 22. After initial management with IV fluids, a cautious dose of pamidronate was given. Basic investigations did not iden...

ea0058oc7.1 | Oral Communications 7 | BSPED2018

DeAPP (Diabetes Education APP): using flipped learning to deliver structured education in newly diagnosed type 1 diabetes patients

Greening James , Lee Sarah Lickwood , Atkins Marie , Terris David

Background: At diagnosis of diabetes is a critical time in the life course of diabetes. This a critical time for patient take on knowledge and using it (ref). Utilisation of this information is suboptimal due to logistical factors such as ward environment, time constraints of staff, psychological impact of the diagnosis. Current models of education are mainly didactic with limited impact in some patients.Aims: In collaboration with demontfort design unit...

ea0081ep105 | Adrenal and Cardiovascular Endocrinology | ECE2022

Serum cortisol immunoassay performance in the overnight dexamethasone suppression test.

Atkins Jonathan , Owen Laura , Clayton Jonathan , Hawley James M , Scargill Jonathan , Keevil Brian

Background: The 1 mg overnight dexamethasone suppression test (ONDST) is recommended for the differential diagnosis of Cushing’s syndrome and the investigation of adrenal incidentalomas. However, diagnostic performance of the test relies on accurate methods to quantitate cortisol in serum. Although the variable performance of serum cortisol immunoassays has been well-documented, little has been published on their performance following the ONDST.Aims...

ea0035p455 | Diabetes complications | ECE2014

The correlation of foetal ultrasound and HbA1c with birth weight in women with gestational diabetes

Stepien Karolina , Rambihar Sophie , Leigh-Atkins Sue , Okinoye Gbemisola , Kyriacou Angelos , Whiteside Sigrid , Issa Basil

Background: It is estimated that gestational diabetes (GDM) accounts for 87.5% of all diabetes cases in pregnancy and is associated with worse pregnancy outcomes. Macrosomia is one of the main complications of GDM and antenatal management strategies are directed at ensuring normal foetal growth. Ultrasonography is a useful tool for estimating foetal size, but there is little data in the literature correlating foetal abdominal circumference (AC) and birth weight in GDM. Further...

ea0039ep61 | Diabetes | BSPED2015

CYPWMDN diabetes awareness education for schools – regional study day

Atkins Marie , Drummond Lesley , Azam Waseema , Collins Louise , Howard Victoria , McCausland Deborah , McEwan Raphaella , Orzechowska Andy , Peasgood Alison , Rumney Chris , Sparkes Paitra , Woods Becky

With the increase in incidence of type 1 diabetes in children and young people (CYP) and the use of intensive insulin therapies, paediatric diabetes teams are under increasing pressure to support school staff with the day to day management of their pupils with diabetes. The CYPWMDN have developed a study day to provide basic diabetes awareness education to all school staff in the West Midlands (WM) region. This work also meets the training and support responsibilities of diabe...

ea0036P43 | (1) | BSPED2014

The effect of the introduction of best practice tariff for paediatric diabetes care on service provision and staffing in the West Midlands

Kershaw Melanie , Atkins Marie , Agwu Chizo , Bone Alison , Brown Sabrina , Brown Jennie , Hinde Frank , McCrea Kathryn , Parakkal Raffeeq , Reynolds Ash , Scanlon John , Salt Gill , Sparkes Paitra , Stirling Heather

Objectives: The Department of Health introduced a Best Practice Tariff (BPT) to finance Paediatric Diabetes Services in England, in response to variation in service provision and outcome. The tariff became mandatory in April 2013 and depends on achievement of 13 quality standards (QS). The West Midlands (WM) Region covers an area of 5020 square miles, where 2700 Children with Diabetes receive care from 15 Hospital Trusts who are members of the Regional Paediatric Diabetes Netw...

ea0058oc6.1 | Oral Communications 6 | BSPED2018

A retrospective regional analysis of outcomes during transition of young people with type 1 diabetes

Kershaw Melanie , Atkins Marie , Digwood Suzanne , McCoubrey Hilary , McGee Marie , Pargass Nisha , Raghavan Rajeev , Rookes Raphaella , Rweyemamu Justina , Sankar Sailesh , Skelding Rebecca , Swift Lesley , Williams Kerrie

Objectives: Transition from paediatric (PC) to adult diabetes care (AC) is a vulnerable period for young people (YP). The West Midlands (WM) Regional Paediatric Diabetes Network conducted a region-wide study of Diabetes transition outcomes to identify 1. Areas of good practice, 2. Risk factors for poorer outcomes, 3. Regional objectives for services and 4. Provide baseline data against which future performance can be measured.Methods: Retrospective regio...

ea0032p686 | Neuroendocrinology | ECE2013

Low carbohydrate/high fat energy intake decreases estrogen receptor alpha expression in the arcuate nucleus of the rat hypothalamus

Zengin Ayse , Bielohuby Maximilian , Horngacher Amon , Meurer Sarina , Bidlingmaier Martin

Low-carbohydrate/high fat diets (LC-HFD) effectively induce body weight loss in both animals and humans; however, in rats this is paralleled by increased visceral adiposity contributing to impaired glucose tolerance. Estrogen inhibits adipose tissue accumulation, with estrogen deficient female animals displaying increased body weight and visceral adiposity with reduced insulin sensitivity, which can be reversed with estrogen replacement. Consistent with the effects seen in fem...

ea0035p83 | Bone and Osteoporosis | ECE2014

Low-carbohydrate/high-fat diets do not have negative effects on bone density in female rats in contrast to male rats

Zengin Ayse , Kropp Benedikt , Chevalier Yan , Horngacher Amon , Sustarsic Riia , Sustarsic Elahu , Benedix Sarina , Herbach Nadja , Milz Stefan , Bielohuby Maximilian , Bidlingmaier Martin

Ketogenic low-carbohydrate/high fat diets (LC-HFD) induce weight loss in both animals and humans. However, a number of unwanted side effects with these diets have been reported. We have previously shown in male rats that LC-HFDs negatively affect bone growth and bone mineral density, possibly due to macronutrient-induced impairments of the GH/IGF-system. Given the importance of dietary macronutrients in the regulation of bone density in male rats, in this study we investigated...