Searchable abstracts of presentations at key conferences in endocrinology

ea0081p138 | Pituitary and Neuroendocrinology | ECE2022

Takayasu’s artheritis presenting as a large sellar mass with neurological and hypopituitarism manifestations

Galazzi Elena , Giancola Noemi , Citterio Valeria , Moro Mirella , Addobbati Laura , Avignone Sabrina , Capsoni Franco , Persani Luca

Introduction: Only one case of hypophysitis secondary to Takayasu’s artheritis (TKA) has been described so far. We report the second case of a TKA presenting with a massive sellar and cerebrovascular infiltration.Clinical case: A 52 years-old female was referred to endocrine outpatient clinics after a brain MRI performed for a 2-year history of headaches, dizziness and general discomfort. Past medical history included hypertension and aspecific symp...

ea0037gp.27.05 | Thyroid – hyperthyroidism and treatment | ECE2015

Effect of a very low dose of rituximab on active moderate–severe Graves' orbitopathy: an interim report

Vannucchi Guia , Campi Irene , Covelli Danila , Curro Nicola , Dazzi Davide , Avignone Sabrina , Sina Clara , Guastella Claudio , Pignataro Lorenzo , Salvi Mario

Previous studies have shown that Rituximab (RTX) is effective as a disease modifying drug at doses of 500 mg or 1000×2 mg in active Graves’ orbitopathy (GO). We have conducted a pilot study (EUDRACT 2012-001980-53) in which patients with active moderate-severe GO were treated with a single infusion of low dose RTX (100 mg). Ten patients were enrolled of whom seven completed the study at 52 weeks. Five patients did not respond to a previous treatment with i.v. methylp...

ea0011p915 | Thyroid | ECE2006

Orbital tissue expansion expressed as a number: usefulness in grading the severity of thyroid-associated ophthalmopathy (TAO)

Vannucchi GM , Campi I , Avignone S , Minetti AM , Guastella C , Sbrozzi F , Beck-Peccoz P , Salvi M

In assessing TAO, orbital CT scan allows measurement of extraocular muscle and optic nerve dimensions but it is useful mainly for a qualitative analysis and cannot be used in the clinical score of the disease. Aim of the present study was to seek a number which could express the expansion of the orbital tissue and be used in grading the severity of TAO. 39 TAO patients and 24 control subjects were studied. We have measured the orbital area (OA) on the central axial section of ...

ea0011p918 | Thyroid | ECE2006

Treatment of patients with Graves’ disease and ophthalmopathy with the anti-CD20 monoclonal antibody rituximab

Salvi M , Vannucchi GM , Campi I , Guastella C , Sbrozzi F , Simonetta S , Rossi S , Bonara P , Avignone S , Ratiglia R

We are conducting an open study on the treatment of Graves’ disease (GD) and thyroid-associated ophthalmopathy (TAO) with the monoclonal antibody to CD-20, rituximab (RTX) (MabThera, Hoffman-Roche, Basel). RTX induces depletion of B cells and GD is typically a B cell dependent autoimmune disease. We present preliminary results on 7 patients with GD and TAO at different clinical stages: 3 women with newly diagnosed GD and initial TAO; 1 woman with GD and moderate-severe TA...