Endocrine Abstracts

This study was conducted to evaluate the frequency of PCOS in a group of FTM transsexual persons and its relationship between clinical, hormonal and metabolic characteristics.Subjects and Methods: We studied 21 FTM cases, aged 17–37 years, BMI 24.6±5.2. No patient reported previous hormonal treatment or sex re-assignment surgery. PCOS was diagnosed according to the Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group, 2004. World Health...

Vesicular thyroid tumours evolve from benign to malignant states, respectively called adenomas and carcinomas by respect to the World Health Organisation classification. Borderline cases, atypical adenomas, cannot be clearly classified. When an abnormal cytoplasmic mitochondrial proliferation occurs into the tumour cells, these tumours called oncocytomas, are more aggressive. Oncogenic mechanisms and signal pathways of these tumours are not well known and the origin of the onc...

Introduction: oxLDL are produced from the oxidation of low density lipoprotein (LDL) by macrophages and endothelial cells, becoming cytotoxic and immunogenic. They are also a potent inhibitor of the macrophages mobility, contributing to the vascular wall progressive inflammatory infiltration and atherosclerosis formation. Weight loss can prevent atherosclerotic plaque progression of and acute coronary events in obese subjects, so that oxLDL could be used a biomarker of cardiov...

Introduction: The gold standard for evaluating Occult Parathyroid Adenomas (OPa) in patients with biochemical pattern of primary hyperparathyroidism (PHPT) is the 99mTc-MIBI parathyroid scan. 18F-Fluorocholine (18F-FCH) PET/CT has been proposed as a potential technique for detection and localization of OPa when 99mTc-MIBI scan is negative or inconclusive.Aims: To evaluate sensitivity and positive predictive value of 18F-Fluorocholine PET/CT in patients w...

Objective: To compare 2 modalities of bolus-basal insulin therapy with aspart-detemir, according to the moment of administration of detemir (DET), before the lunch or bed-time, in type 1 diabetic patients with poor metabolic control.Methods: We conducted a prospective study of 40 type 1 diabetic patients, with poor metabolic control (HbAc 7–12%), randomized to receive treatment with 1 injection of DET before the lunch or bed-time and followed-up dur...

Objectives: We have examined the relationship between the hepatic enzymes and type 2 diabetes. We have analyzed if the levels of hepatic enzymes are associated with body weight, lipid profile and the treatment with metformin, thiazolidinediones or statins.Methods: 318 patients with type 2 diabetes were included and they were compared with 100 healthy subjects. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gammaglutamiltranspeptidas...

Introduction: We present the results of chemoembolization used as a locoregional treatment for liver metastases (on a transplanted liver) from a bronchial carcinoid neuroendocrine tumor with stage IV disease progression.Case report: A 60-year-old man diagnosed of bronchial carcinoid NET in 2002, underwent surgery by lung lobectomy and excision of lymph node metastases. Treated also with somatostatin analogues (SA) after subsequent discovery of liver meta...