Endocrine Abstracts

Background: Adipose tissue dysfunction, such as adipocyte hypertrophy and secretion of pro-inflammatory cytokines, develops in obese subjects and goes hand in hand with obesity-related complications, especially insulin resistance (IR) and systemic inflammation. The exact mechanisms underlying adipose tissue dysfunction and consequently the obesity-related complications are not yet fully understood.Aim: Investigate the association between systemic IR and ...

Background and aim: Adipose and muscle tissue dysfunction are associated with obesity-related complications, especially insulin resistance (IR) and inflammation, which improve after weight loss. The underlying mechanisms are however not yet fully understood. This study investigates changes in systemic and regional markers of IR and inflammation during weight loss in subjects with obesity.Materials and methods: Twenty subjects with obesity (age 49±10...

Background: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p class="abs...

Background and aims: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p c...

BackgroundPrecise diagnostics for postprandial reactive hypoglycaemic syndrome (PRHS) after gastric bypass surgery (GBS) are lacking. Oral glucose tolerance tests are advocated but might cause early dumping in this population and often cause hypoglycaemic values in a normal population.AimTo evaluate glycaemic responses during liquid and solid mixed meal tolerance tests (LMMTT and SMMTT) in a post-GBS populati...