Searchable abstracts of presentations at key conferences in endocrinology

ea0082p19 | Poster Presentations | SFEEU2022

Amiodarone-induced thyroiditis, complicated by a thyroid storm in a man with Becker Muscular Dystrophy

Rathore Yashasvini Gosavi1, Shadman Ahmed2, Lauren M Quinn2, Neil Sharma2 & Kristien Boelaert2

Section 1: Case history: A 46 year old man with Becker Muscular Dystrophy (BMD), was admitted with palpitations and shortness of breath. He had a past medial history of severe left ventricular dysfunction (LVSD) and cardiac arrhythmias, including atrial fibrillation (AF) treated with amiodarone, and an implantable cardiac defibrillator (ICD) for non-sustained ventricular tachycardia (VT). He had been treated with 3 months of prednisolone for suspected type 2 amiodarone induced...

ea0044s4.2 | Advances in the genetic understanding of endocrine disease | SFEBES2016

Applying new developments in the genetic understanding of inherited pituitary adenoma

Beckers Albert

There are a number of established and recently identified inherited or congenital forms of growth hormone (GH) secreting pituitary tumors. These may be caused by an abnormality in the genetic sequence of responsible genes including MEN1, AIP, CDKN1B, and PRKAR1A. Copy number variation for these and other genes may also contribute to pituitary tumorigenesis, such as duplication of the gene GPR101 in X-linked acrogigantism (X-LAG) syn...

ea0041gh1 | The Geoffrey Harris Prize Lecture | ECE2016

Beyond the Adenoma Valley: from FIPA to gigantism and back

Beckers Albert

‘Je résolus de m’informer du pourquoi, et de transformer ma volupté en connaissance’ Baudelaire.One of the great blessings in life is to be able to work at something that inspires and interests you. For me, exploration of the diseases caused by abnormal neuroendocrine function has been my passion. Its complexity and interlinked nature can be both startlingly confusing and, when better understood, remarkably logical. But above all...

ea0026mte21 | (1) | ECE2011

To whom to offer genetic analysis in patients with pituitary adenoma

Albert Beckers

Genetic predisposition to pituitary adenomas is increasingly recognized and extends beyond diseases such as MEN1 and Carney complex to familial isolated pituitary adenomas (FIPA). A genetic predisposition occurs in >5% of all pituitary adenoma cases, with MEN1 and FIPA comprising the vast majority of these. The identification of the AIP gene as a predisposition gene for pituitary adenomas in 15–25% of FIPA kindreds and in a significant number of young patients ...

ea0022s8.3 | Endocrine tumours: new genes and association with syndromes | ECE2010

Update on familial pituitary tumors: from multiple endocrine neoplasia type I to familial isolated pituitary adenomas

Beckers Albert

Inherited genetic conditions associated with pituitary tumours include multiple endocrine neoplasia type I (MEN-I) and Carney complex. Pituitary tumours that occur in the setting of MEN-I and Carney complex have specific clinical characteristics in terms of severity, which can help to guide clinical management. In 2000, we reported the first series of 27 patients with FIPA. Later on, the number of FIPA families has increased to more than 130 today.In 200...

ea0071011 | Multiple endocrine neoplasia type 1: a single center-based series | BES2020

Multiple endocrine neoplasia type 1: A single center-based series

P Delannoy , P Petrossians , A Beckers

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the MEN1 gene (a tumor supressor gene) leading to the development of endocrine and non-endocrine tumours with variable penetrance.The most frequent features are primary hyperparathyroidism, duodeno pancreatic endocrine tumours and pituitary adenomas.Aim of the work: The aim of this retrospective study was to establish the pre...

ea0064006 | Endocrine consequences of immune checkpoint inhibitors | BES2019

Endocrine consequences of immune checkpoint inhibitors

Chachati A-S , Potorac I , Petrossians P , Beckers A

Immune checkpoints inhibitors have fundamentally changed the management of oncologic patients. These treatments consist of monoclonal antibodies directed against CTLA-4 (cytotoxic T-lymphocyte antigen 4), PD-1 (programmed cell death protein-1) and PD-L1 (one of its ligands). By blocking these receptors or ligands, the antibodies reverse the immune tolerance induced by the cancerous cell on the T-lymphocyte and favour lymphocytic reactivation and anti-tumor activity. Immune tol...

ea0037ep120 | Steroids, development and paediatric endocrinology | ECE2015

Six-month interim safety and efficacy of different dose levels of transCon hGH administered once weekly versus standard daily human growth hormone replacement therapy in pre-pubertal children with growth hormone deficiency (GHD)

Chatelain Pierre , Malievsky Oleg , Radziuk Klaudziya , Elsedfy Heba Hassan , Mikhailova Evgenia , Beckert Michael

Background: TransCon hGH is a long-acting prodrug of recombinant human GH (hGH) that releases into the blood compartment fully active unmodified hGH. TransCon hGH was shown in two Phase 1 studies and a Phase 2 study in AGHD to be safe and well tolerated and inducing an IGF-I pharmacodynamic response within the normal range throughout the dosing period. This interim analysis consists of 25 patients completing all 6 months of treatment.Objectives: The obje...

ea0064008 | Study of neuroendocrine deficits in a series of 74 patients following traumatic brain injury | BES2019

Study of neuroendocrine deficits in a series of 74 patients following traumatic brain injury

Daniel S , Valdes-Socin H , Bonneville JF , Petrossians P , Beckers A

Aim of the work: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, these endocrine anomalies remain under diagnosed due to nonspecific clinical signs and misunderstanding of the phenomenon. The aim of the work is to evaluate for the first time in Belgium their prevalence and to quantify the deficits of the different pituitary axes in patients recruited to the endocrinolo...

ea0063p1104 | Pituitary and Neuroendocrinology 3 | ECE2019

Prevalence and study of neuroendocrine deficits in a series of 75 patients following traumatic brain injury

Daniel Sara , Bonneville Jean-Francois , Beckers Albert , Valdes-Socin Hernan

Introduction: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, these endocrine anomalies remain underdiagnosed.Patients and methods: We are studying data from a series of 75 TBI patients. They had a basal hormonal test, and dynamic confirmation tests if necessary. Somatotropic deficiency was defined by growth hormone (GH) remaining under 3 μg...