Searchable abstracts of presentations at key conferences in endocrinology

ea0004s20 | Maintenance of pregnancy | SFE2002

Endocrinology of labour and pre-term complications

Bennett P

In most species progesterone acts to inhibit cervical ripening and myometrial contractility throughout pregnancy and labour is heralded by prostaglandin stimulated withdrawal of progesterone. Human labour is associated with increased prostaglandin synthesis, via COX-2 but there is no clear systemic withdrawal of progesterone at the time of labour. There is upregulation of genes which are normally repressed by progesterone leading to the concept that human labour is associated ...

ea0077p203 | Metabolism, Obesity and Diabetes | SFEBES2021

An Audit assessing Management of COVID patients on Dexamethasone with High Capillary Blood Glucose (CBGs) from 01/01/21 to 19/3/21

Choy Bennett , Mannan Imran

Dexamethasone reduces mortality in COVID patients who require oxygen therapy. Dexamethasone-related hyperglycaemia however is a known complication. Capillary blood glucose (CBGs) above 10.0 mmol/l have been linked to increased mortality in COVID patients. Approximately a third of COVID patients with dexamethasone-related hyperglycaemia may develop diabetes later. It is therefore important to manage acute episodes of hyperglycaemia effectively and identify these patients for fo...

ea0004p9 | Clinical case reports | SFE2002

CONGENITAL HYPOPITUITARISM PRESENTING AS ADULT-ONSET HYPOGONADOTROPHIC HYPOGONADISM

Bennett S , Quinton R

We present a case of acquired hypogonadotrophic hypogonadism (HH) in a 54-year-old man that illustrates the need for wider endocrine screening in such patients. Having undergone complete pubertal development as a teenager and subsequently fathered two children, the patient presented with a nine-month history of reduced libido, erectile dysfunction, hot sweats and headaches. His GP had diagnosed HH on the basis of a low testosterone with inappropriately low gonadotrophins. Exam...

ea0069p57 | Poster Presentations | SFENCC2020

Severe symptomatic hyponatremia with SIADH picture due to influenza A

Rashid Razan Ali , Bennett Stuart

Case history: A previous healthy 69 year-old female was brought into the ED by her worried husband after he noticed worsening confusion. She developed seizures post arrival to the ED and was admitted under ITU for further care. Retrospective history from the husband indicated she had started feeling unwell around Christmas with a feeling of malaise. She self-medicated with amoxicillin which she had access to as a nurse practitioner. Over the next 2 days she developed headaches...

ea0002oc1 | Signalling from Cell Surface to Nucleus | SFE2001

Identification of a putative receptor for N-POMC peptides

Bicknell A , Bennett H , Lowry P

In respect to growth, the adrenal is a dynamic organ that requires constant stimulation from peptides derived from the ACTH precursor pro-opiomelanocortin (POMC) to maintain its tonic state. Previous studies have suggested that the adrenal mitogen resides in the N-terminus of pro-gamma-MSH, which upon cleavage results in the generation of shorter mitogenic peptides not containing the gamma-MSH sequence. This hypothesis has recently been substantiated by our characterisation of...

ea0065p87 | Bone and calcium | SFEBES2019

Investigations in preparation for surgically managed primary hyperparathyroidism

Bennett Robert , Brooke Antonia , Dunn Julie

Background: Recent NICE guidelines1 suggest imaging the parathyroid with ultrasound as first line prior to parathyroidectomy, MIBI as an alternative and surgical exploration if discordant. Investigation should also include a renal ultrasound and DEXA. This audit compares a single surgeon practice in one hospital to the guidelines.Methods and Results: All patients with a parathyroidectomy performed by a single surgeon between July 2016 and July...

ea0059ep13 | Adrenal and steroids | SFEBES2018

A rare cause of unexpected bilateral adrenal gland abnormalities

Devine Kerri , James Andy , Bennett Stuart

Adrenal gland anomalies are common incidental findings when imaging tests are performed for other reasons, but are usually unilateral. We present a case where bilaterally abnormal adrenal glands held the key to a rare diagnosis. A 79 year old female ex-smoker with a background of Type 2 Diabetes Mellitus and hypertension presented to our emergency department with a four month history of falls and progressive decline in mobility. Examination revealed evidence of weight loss, wi...

ea0028p104 | Clinical practice/governance and case reports | SFEBES2012

In-patient insulin prescriptions: Legal? Correct? Appropriate?

Sugrue Michelle , Bennett Luke , Cranston Iain

Patients with diabetes represent 15-20% of the total adult population in UK hospitals. Insulin is now recognised as the drug with the highest number of prescribing errors in the NHS. In order to determine insulin-related glycaemic morbidity we reviewed a random representative sample of 50 insulin prescription and administration records (25 medical and 25 surgical)over a 4 week period (11 T1DM, 39 T2DM) Initially we audited the legality of the prescriptions against well-describ...

ea0013p239 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

I am rare Turner mosaic – Can I have a baby?

Bennett Rachel , Chowdhury Sharmistha Roy , Page M.D.

Case History: A 16 yr old patient presented to us concerned about her short statue. Her father and mother were at the 9th centile and her sister was at the 25th centile in adult life. She was otherwise well having gone through a normal puberty in her early teens and was currently on the oral contraceptive pill having regular periods. On examination she did display some features of Turner’s syndrome; short stature, short neck and cubitus valgus deformity. Cytogenetic analy...

ea0002p78 | Reproduction | SFE2001

Alternative splicing of 15-hydroxyprostaglandin dehydrogenase (PGDH) in human chorio-decidua, placenta and myometrium

Slater D , Kirk R , Bennett P

Prostaglandins are strongly implicated in the onset and maintenance of human parturition and their synthesis is increased within the uterus in association with labour. Enzymes involved in their synthesis, (cyclo-oxygenase-2), and catabolism, (prostaglandin dehydrogenase) are up and down-regulated respectively, in association with labour. The human prostaglandin dehydrogenase (PGDH) gene is approximately 34kb in size. A large 5' promoter region containing numerous potential tra...