Endocrine Abstracts

Introduction: Digital necrosis of the upper limbs is the final and often the only clinical manifestation of a of a distal arterial or microcirculatory pathology of the MS. The approach to The approach to this condition is very different, hence the particularity of our observation which highlights the severity of vascular lesions found in diabetic patients.Observation: This is a 58 year old diabetic patient on mixtard 30: 16-00-08 ui; schizophrenia; on cl...

The human prostate is highly susceptible to benign and malignant proliferative changes and is associated with the development of benign prostatic hyperplasia (BPH) and prostate cancer (PCa), two of the most common diseases affecting elderly males. The diseased-associated stroma undergoes significant remodelling, including fibroblast-to-myofibroblast/smooth muscle cell transdifferentiation. Subsequent increased secretion of cytokines and growth factors generates a growth favour...

Differentiated thyroid cancer is rare in children and adolescents. An aggressive clinical presentation, together with a high rate of recurrences contrasting with low mortality, has been reported, especially, before the age of 15 years. Data are mainly issued from historical series from hospital databases.The aim of the study was to analyze, from a population-based registry, the clinical presentation and outcome of differentiated thyroid cancer in young s...

Background: Diabetic retinopathy (DR) is a chronic diabetic complication occurring in most diabetic patients after 20 years of disease. Progression of DR to its sight threatening stages is usually associated with worsening of underlying retinal vascular dysfunction and disease. The plasma kallikrein kinin system is activated during vascular injury, mediating important functions in inflammation, blood flow, and coagulation. Bradykinin B1 receptor (B1R) is expressed in human ret...

Benign prostatic hyperplasia (BPH) is characterized by tissue overgrowth and stromal reorganization primarily due to cellular proliferation and fibroblast-to-myofibroblast transdifferentiation. Given the recently reported beneficial effects of PDE5 inhibitors on lower urinary tract symptoms secondary to BPH this study aimed to investigate the influence of PDE5 inhibition on the prostate at a cellular level. We investigated the expression of PDE5 in the human prostate and demon...

Prostate homeostasis and function are regulated by complex interactions between the fibromuscular stroma and secretory epithelium via locally-derived and systemic paracrine- and autocrine-acting growth factors and sex steroid hormones. Stromal tissue remodelling due to alterations in transforming growth factor beta (TGF-β) and sex steroid hormone signalling are associated with benign prostatic hyperplasia (BPH) and prostate cancer (PCa), two of the most common proliferati...

Chronic stress is a pervasive concern in the modern society. A long-term hyper activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to elevated amounts of stress hormones [e.g. ACTH and glucocorticoids (GCs)]. This can incur maladaptation that eventually contributes to mental illness, cardiovascular dysfunctions, diabetes, cancer and autoimmune diseases. Emerging key players for stress adaptation of the HPA axis are stem/progenitor cell populations. In this study,...

Recent reports have revealed that leptin’s effects are not restricted to central control of body weight, demonstrating instead that leptin is a pleiotropic hormone with a wide variety of different biological actions. Leptin exhibits undesirable effects in autoimmune diseases, in atherosclerosis, and possibly in several types of cancer, and increases the risk of cardiovascular disease in obese people. Therefore, preparation of reagents capable of abolishing leptin’s a...

A tightly regulated stress system is pivotal for health and the adrenal cortex is a master regulator of the endocrine stress response. The adrenal cortex is characterized by constant cell renewal in part mediated by differentiation and lineage conversion of undifferentiated cell types. To date, the contribution of stem cells to organ plasticity during stress has been implicated but is not fully understood. Recently, we were able to show that a prolonged stress exposure leads t...

In the Rhône Alpes region, that hosts more than 5.6 million inhabitants; thyroid illnesses are still rather common with 3,600 operations on the thyroid gland per year, comprising 650 incident cases of cancer. A progressive increase in the incidence of thyroid cancer was suspected in the 1990 s and a population based register was initiated. The collection consists of histological data validated and obtained directly from pathologists, surgical wards and controlled through ...