Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp204 | Thyroid 1 | ECE2017

24-month efficacy of a single radiofrequency ablation on autonomously functioning thyroid nodules

Bernardi Stella , Stacul Fulvio , Michelli Andrea , Calabro Veronica , Giudici Fabiola , Dobrinja Chiara , Fabris Bruno

Background: Radiofrequency ablation has been advocated as an alternative to radioiodine and/or surgery for the treatment of autonomously functioning benign thyroid nodules. However, only a few studies have measured radiofrequency ablation efficacy on autonomously functioning benign thyroid nodules. The aim of this work was to evaluate the 24-month efficacy of a single session of radiofrequency ablation (performed with the moving shot technique) on solitary autonomously functio...

ea0037gp.25.02 | Thyroid – nodule | ECE2015

Thyroid hormones influence the expression of TNF-related apoptosis-inducing ligand

Bernardi Stella , Bossi Fleur , Giudici Fabiola , Secchiero Paola , Zauli Giorgio , Fabris Bruno

Background: There is growing evidence supporting TNF-related apoptosis-inducing ligand (TRAIL) involvement in weight and body composition regulation, which are classically influenced by thyroid hormones. This study aimed at investigating the relationship between thyroid hormones and TRAIL.Methods: Circulating TRAIL was measured in 40 controls, 40 hyperthyroid, and 25 hypothyroid patients before and after their respective treatments. In the same patients ...

ea0037ep960 | Thyroid (non-cancer) | ECE2015

Surgical and pathological changes after radiofrequency ablation of thyroid nodules

Dobrinja Chiara , Bernardi Stella , Fabris Bruno , Eramo Rita , Makovac Petra , Bazzocchi Gabriele , Zanconati Fabrizio , Stacul Fulvio

Background: Radiofrequency ablation (RFA) is an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent RFA may affect thyroid surgery and/or histological diagnosis.Materials and methods: patients were treated with RFA and then followed for 2 years. RFA was performed on 64 symptomatic Thy2 nodules and on six symptomatic Thy3 nodules, without atypical cells nor BRAF or NRAS mutations, in surgically high-...

ea0070aep986 | Thyroid | ECE2020

A retrospective 5-year follow-up study on the outcomes of radiofrequency ablation for the treatment of benign thyroid nodules

Zuolo Giulia , Giudici Fabiola , Marco Cavallaro , Calabrò Veronica , Bruno Fabris , Stacul Fulvio , Bernardi Stella

Background: During the last decade, radiofrequency ablation (RFA) has emerged as a reliable alternative to surgery for the treatment of benign symptomatic thyroid nodules in terms of effectiveness and safety.Aim: The aim of this study were: (i) to evaluate the long-term efficacy (5 years) of RFA for the treatment of benign thyroid nodules, in terms oftechnical success and nodule regrowth, and (ii) to identify the predictive factors of t...

ea0056oc4.3 | Novel insights into prediabetes and type 2 diabetes | ECE2018

Effects of TRAIL delivery on an experimental model of type 2 diabetes and diabetic nephropathy

Bernardi Stella , Toffoli Barbara , Tisato Veronica , Lorenzon Andrea , Zauli Giorgio , Secchiero Paola , Fabris Bruno

Introduction: Experimental studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) has the potential to treat type 2 diabetes mellitus (T2DM). We have recently demonstrated that TRAIL delivery ameliorates T2DM in the high-fat diet-fed mouse. This study aimed at evaluating whether TRAIL had the potential to treat not only T2DM but also diabetic nephropathy.Methods/design: Based on this background, 15 male db/H mice ...

ea0090p577 | Calcium and Bone | ECE2023

Trabecular bone score increases the proportion of patients with asymptomatic primary hyperparathyroidism meeting surgical criteria

Malagrino Matteo , Piazza Anna , Bisceglia Nicolo , Bernardi Boari Marcello , Vandi Giulia , Altieri Paola , Pagotto Uberto , Zavatta Guido

Context: Several studies have shown that Trabecular Bone Score (TBS) predicts fractures independently of Bone Mineral Density (BMD) measured with Dual Energy X-ray Absorptiometry (DXA), even in patients with Primary Hyperparathyroidism (PHPT), known to have deteriorated bone microarchitecture. Low TBS values alone are still not considered as a single criterium to recommend parathyroid surgery. Measuring bone quality in patients with PHPT may be helpful to identify a proportion...

ea0090p226 | Thyroid | ECE2023

A retrospective study on the immunocitochemistry profile of benign thyroid nodules unresponsive to thermal ablation

Bernardi Stella , Taccogna Silvia , D'Angelo Martina , Giudici Fabiola , Mauri Giovanni , Raggiunti Bruno , tina doris , Zanconati Fabrizio , Papini Enrico , Negro Roberto

Objective: Thermal ablations (TA) are gaining ground as alternative options to conventional therapies for symptomatic benign thyroid nodules. Little is known on the impact of nodule biology on the outcomes of TA. The aim of our study was evaluating the baseline immunocytochemistry profile of thyroid nodules that are poorly responsive to TA, in order to identify potential predictors of treatment response.Methods: we retrospectively selected by propensity ...

ea0063p1002 | Environment, Society and Governance | ECE2019

Observational study on the cardio-metabolic effects of a night shift on internists

Bernardi Stella , Toffoli Barbara , Ferretti Tommaso , Francica Morena , Ghirigato Elena , Rovina Matteo , Calabro Veronica , Stenner Elisabetta , Giudici Fabiola , Fabris Bruno

Introduction: Shift work has been associated with increased cardiovascular morbidity and mortality. Several studies have demonstrated that shift work has an effect on cardiovascular and metabolic health. Most of these studies have compared different groups of shift workers to nonshift workers. By contrast, the present work aimed to evaluate the cardio-metabolic effects of night shifts on the same group of internists as they changed type of duty. In particular, we focused on bl...

ea0041oc6.3 | Diabetes therapy & complications | ECE2016

TRAIL treatment reduces high-fat diet-induced hyperglycemia and hyperinsulinemia

Bernardi Stella , Bossi Fleur , Tisato Veronica , Biffi Stefania , Lorenzon Andrea , Toffoli Barbara , Zauli Giorgio , Secchiero Paola , Fabris Bruno

Introduction: Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) may have an important role in the treatment of type 2 diabetes mellitus (T2DM). It has been shown that TRAIL deficiency worsens T2DM and that TRAIL delivery, when it is given before disease onset, slows down T2DM development. This study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat T2DM.Methods/...

ea0070aep778 | Reproductive and Developmental Endocrinology | ECE2020

Case-control study on ACE2 expression in children with short stature

Tornese Gianluca , Tonon Federica , Nicolardi Francesca , Toffoli Barbara , Chiara Pellegrin Maria , Barbi Egidio , Fabris Bruno , Bernardi Stella

Background: Short stature is one of the most common presentations to paediatric endocrinologists. It is estimated that despite all the exams, in 50–90% of cases, children are labelled as having idiopathic short stature. It has been recently reported that genetic ACE2 deficiency is associated with reduced body weight as well as with impaired gestational weight gain and fetal growth restriction in pregnancy. It has been argued that ACE2 deficiency, which is usually associa...