Endocrine Abstracts

Background: PWS is a rare genetic neurodevelopmental disorder characterized by hyperphagia, obesity, hormonal deficiencies, and problem behaviors for which there is no approved treatment. DESTINY PWS (C601) was an international, placebo-controlled, Phase 3 study of DCCR (diazoxide choline) extended-release tablet in participants with PWS, age 4 and older with hyperphagia. C602 is a long-term, open label extension to C601. DCCR administration to participants with PWS in these s...

Background: The autoimmune thyroid diseases, primary autoimmune hypothyroidism (AH) and Graves’ hyperthyroidism (GD), represent the most prevalent endocrine disorders. Although clinically distinct, they share several genetic susceptibility loci, many of which remain unidentified.TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domains), expressed on the surface of T-cells, interacts with CD-155 on dendritic cells to form an alternative cost...

Endothelial dysfunction (ED) is common in type 2 diabetes mellitus (T2DM) and can lead to microvascular and macrovascular complications. The aim of our study was to assess ED in patients with T2DM (n=21; 13 with diabetic neuropathy (DN), 8 without DN) and compare them with non-diabetic controls (n=10).Methods: ED was assessed by skin microcirculation (SM) and biochemical markers (BM) of endothelial function. SM was measured on the dorsu...

Type 2 diabetes mellitus (T2DM) and obesity are linked to osteoporosis, making these patients at increased risk of developing fractures. In this study we aimed to investigate bone biochemical markers and bone structure in diabetic patients to compare with non-diabetic controls.Methods: We recruited 21 type 2 diabetic patients and 10 non-diabetic controls. Fasting blood samples were collected for markers of bone turnover (Sclerostin (SCL), RANKL, OPG, OPN...

Introduction: Propensity to centripetal adiposity is an ethnic characteristic amongst South Asians, which may underlie the excess risk for both coronary heart disease (CHD) and diabetes in this population. Circulating levels of adipocytokines (hormones which include leptin, adiponectin, tumour necrosis factor (TNF-alpha)) and C-reactive protein (CRP) reflect the adipose tissues endocrine and metabolic activity, and are implicated in CHD.Methods: We compa...

IntroductionThe IGF-system has also been implicated in the pathogenesis of diabetes and cardiovascular disease. We report the effects of total energy intake on the IGF-system in two populations with a markedly different dietary macronutrient intake and cardiovascular event rate.MethodDietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell UK (n=205) compared with people ...

Introduction: Compared to ethnically European men, Pakistani origin men living in the UK have a lower circulating total and free testosterone level, corresponding with greater central adiposity and higher insulin resistance. Within a South Asian group we have now examined the effect of migration to the UK on male testosterone level.Methods: Circulating testosterone concentration was measured by automated immunoassay in 97 Gujarati males resident in India...

Background: PWS is a rare neurodevelopmental genetic disorder characterized by hyperphagia, obesity, hormonal deficiencies, and problem behaviors for which there are no approved treatment. DCCR administration (100-525 mg/day) up to 52 weeks in participants with PWS improved hyperphagia, behavior, body composition and metabolic markers.Objective: The objective of this study was to compare changes in hyperphagia (using Hyperphagia Questionnaire for Clinica...

Background: Prader-Willi syndrome (PWS), a rare genetic neurobehavioral-metabolic condition, is characterized by hyperphagia, accumulation of excess fat, hypotonia, and behavioral/psychological complications. There are no currently approved medications to treat hyperphagia in patients with PWS; DCCR is under development as a treatment for PWS.Objectives and Methods: The objective was to evaluate long-term safety of DCCR in individuals with PWS. 125 parti...