Endocrine Abstracts

Background: Serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are useful indicators of inflammation in patients with sub-acute thyroiditis. Despite the widespread use of several diagnostic tests, the purpose of this study was to compare the usefulness serum CRP and ESR in deciding which patient requires of glucocorticoid therapy.Methods: A total of 28 patients with sub-acute thyroiditis, included in this study. Serum CRP and ESR mea...

Section 1: Case history: A 17 year old lady who was referred to our endocrinology clinic due to primary amenorrhoea in 2019. She had well-established secondary sexual characteristics and hyperprolactinaemia. Patient mentioned one episode of PV bleed when she was about 10 years old. Section 2: Investigations: Bloods (Feb2020) showed: FSH: 6.2 IU/l; LH: 5.1IU/l; prolactin 1.048 mIU/l; testosterone 1.3 nmol/l. MRI pituitary: lipoma of corpus calosum and pit...

Case history: This 28 year old lady with a new diagnosis of T1DM (April 22) and uveitis complained of severe pain over the trunk described as a burning sensation but not associated with any neurological deficit. There is no history of head trauma, neck trauma or radiation to head and neck area and no skin changes or spinal deformity. She has developed this pain after starting insulin in April 22. Investigations: May 22: Hb 119, MCV: 85.0; U&Es:normal...

We present the case of a 32-year-old gentleman who was reviewed in the endocrinology clinic for hypogonadotropic hypogonadism and he was investigated for persistent HTN. His only symptoms were anxiety and palpitations. We have controlled his blood pressure with doxazosin 10 mg BD and bisoprolol 1.25 mg OD. Investigations: bloods (Jan 23) normetanephrine:3,460 picomole/l, metanephrine:120 picomole/l, aldo/renin ratio: 92, TSH 2.3, prolactin 307, IGF-1: 26,6, testosterone: 5,9 n...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise. It is associated with an increase in mortality and length of stay, independent of diagnosis and clinical variables. Despite this it is often inadequately investigated and poorly managed. As a number of endocrine conditions can cause hyponatraemia, endocrinologists often have the necessary clinical skills and expertis...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise (1). Proton pump inhibitors (PPI’s) are commonly prescribed in the UK, and the indication and duration of treatment is often not reviewed.Methods: A retrospective audit was performed of patients admitted to The Great Western Hospital (GWH) with a serum sodium of 127 mmol/l or less on admiss...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise. It is associated with an increase in mortality and length of stay, independent of diagnosis and clinical variables. Despite this it is often inadequately investigated and poorly managed.Methods: A retrospective audit was performed of patients admitted to The Great Western Hospital (GWH) serum s...

Introduction: Hyponatraemia is common and associated with significant morbidity and mortality. However, it’s often not recognised as a serious diagnosis and therefore inadequately investigated and poorly managed. An audit of the management of patients admitted to The Great Western Hospital (GWH) with hyponatraemia confirmed these problems. A hyponatraemia guideline was produced in order to improve diagnosis, investigation, and management of patients with hyponatraemia.</p...

Fasting blood glucose is key to diagnosing diabetes, whilst the Oral Glucose Tolerance Test (OGTT) is a valuable adjunct when diagnosis is borderline or inconclusive. The OGTT is often used to detect early changes in glucose tolerance and predict a likely path to overt Diabetes Mellitus for example in gestational diabetes.A 42 year old female, referred to the Endocrine services for episodes of symptomatic hypoglycaemia. Past medical history included pylo...

Hyperparathyroidism occurs in most patients with MEN Type 1 but the association of MEN type-1 with parathyroid carcinoma has only been described previously in one patient. In this report, we describe two further cases of parathyroid carcinoma presenting in association of MEN type 1 syndrome.The first patient was a 69-year-old woman who presented with severe hyperparathyroidism and tracheal compression by a mediastinal mass which was shown histologically ...