Searchable abstracts of presentations at key conferences in endocrinology

ea0011p247 | Cytokines and growth factors | ECE2006

IGF-I modulates HIF-1α and HIF-2 α in Kaposi Sarcoma

Catrina SB , Botusan IR , Rantanen A , Catrina AI , Pyakurel P , Axelson M , Biberfeld P , Poellinger L , Brismar K

Neoangiogenesis is essential for tumor development. Hypoxia inducible factor (HIF), a transcriptional factor composed of two subunits (α and β) plays a key role in this process, activating proangiogenic factors, such as VEGF. The HIF α subunits are critically regulated by oxygen but also modulated by growth factors. Kaposi Sarcoma (KS) is a highly vascular tumor which releases large amounts of VEGF and for which we have recently described an essential role for I...