Endocrine Abstracts

Therapeutic response for medical therapy in hormonally functioning pituitary tumours is different in various types of tumours. While majority of prolactinomas respond well for medical therapy using dopamine agonists, in other tumours like somatotropinoma or corticotropinoma their response is significantly lower. In some case therapy resistance can occur. There are various factors determining the efficacy of medical therapy in patients harboring functioning pituitary adenomas. ...

Different hormonal disorders can influence bone metabolism and cause secondary osteoporosis. In childhood, pituitary disorders hamper gaining of proper peak bone mass and skeletal size, later on in the adult life they can increase bone loss. The consequence of diminished bone strength is significant increase of fracture risk. Among pituitary disorders such effects are possible in patients with GH, prolactin, gonadotropins secretion disturbances, and GH and ACTH excess, while h...

Radiotherapy of brain tumours given to children and adults is connected with various hormonal dysfunctions later in the life. There are anterior pituitary hormones deficiencies, hyperprolactinemia and precocious puberty. Their severity and frequency depends on the dose applied, age of the radiotherapy and time after radiotherapy. In children, the most important is early recognition of them, with growth hormone deficiency as most common. The impact of cranial irradiation on gon...

Osteoporosis is the most common metabolic bone disease. It represents significant burden due to fractures and costs for the health system and individuals. There are several factors which increase the risk of osteoporosis, genetic, hormonal and environmental influences are the most important. The primary goal of early intervention is to prevent the fractures. This could be carried out by the influence on bone density and quality, normalization of bone turnover, regulation of ho...

It has been reported that orexins play an important role in the regulation of GH secretion. It is suggested that the defect in orexins synthesis could be responsible for the disturbances in GH synthesis and consequently aggravate metabolic disturbances. The aim of the study was to assess plasma orexin A levels in patients with acromegaly in relation to the activity of disease and hormonal and metabolic profiles. Fifty-five patients with acromegaly divided into three groups acc...

Patients with acromegaly have 2–3 fold increased mortality from cardiovascular diseases. It is associated with elevated growth hormone (GH) levels. Alterations of acute phase proteins, observed in patients with acromegaly, could lead to increased cardiovascular mortality. There are limited data on influences of GH excess on acute phase reactants.The aim of the study was to evaluate selected acute phase proteins levels: fibrinogen and C-reactive prot...

Obesity and overweight are nowadays very important health problems. Metabolic syndrome increases the risk of diabetes mellitus and coronary heart disease. Patients suffering from metabolic syndrome, especially males, are at greater risk of acute cardiovascular episodes, like heart infarct or brain stroke, than patients without this, widely accepted atheromatosis’ risk farctor. The aim of the study was assessment of possible relations of PPARγ genetic polymorphism and...

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

Acromegaly is associated with various skeletal deformities and in some cases with bone deterioration. The aim of the study was to assess the skeletal status using quantitative ultrasound (QUS) in patients suffering from acromegaly. A group of 38 patients with acromegaly (27 women and 11 men) in mean age of 57.21±9.85 y in various gonadal status was compared with a control group matched for sex, age and body mass. QUS measurements at hand phalanges were performed with DBM ...

Acromegaly causes various cardiovascular dysfunctions, and cardiovascular complications are the main cause of increased mortality in non-cured acromegalic patients. The aim of the study was assessment of flow mediated dilatation (FMD) and the concentration of soluble vascular cell adhesive molecule (sVCAM) as the selected markers of endothelial dysfunction in patients suffering from acromegaly. The study was carried out in 40 patients with acromegaly in various stages of the d...