Searchable abstracts of presentations at key conferences in endocrinology

ea0028s3.3 | Testosterone in men: how long can you go? | SFEBES2012

What is the best form of testosterone replacement therapy (TRT) ?

Bouloux Pierre-Marc

The current indication for TRT is hypogonadism, a syndrome complex combining hypogonadal symptoms and low testosterone concentrations. The optimal formulation for the treatment of hypogonadism is one that generates a physiological testosterone concentration in the age adjusted reference range, as well as the concentration of its metabolites oestradiol and dihydrotestosterone, while ideally mimicking the circadian rhythm in younger subjects. Optimal treatment should lead to cor...

ea0034p60 | Clinical practice/governance and case reports | SFEBES2014

Characteristics, comorbidities and aetiology of hospitalised patients with hyponatraemia

Tzoulis Ploutarchos , Bouloux Pierre Marc

Introduction: Hyponatraemia is the most common electrolyte abnormality encountered in hospitalised patients.Methods: This retrospective study included all inpatients with serum sodium ≤128 mmol/l at any point during their hospital stay between 1st March 2013 and 31st May 2013. Full review of medical case notes and laboratory results was undertaken in order to determine the comorbidities, drug history and aetiology of inpatients with hyponatraemia.<...

ea0034p63 | Clinical practice/governance and case reports | SFEBES2014

Analysis of hyponatraemic inpatients who died in a teaching hospital

Tzoulis Ploutarchos , Bouloux Pierre Marc

Introduction: Hyponatraemia is associated with increased inpatient mortality, but there is debate about whether hyponatraemia per se contributes to mortality or is merely an epiphenomenon of severe illness.Methods: This retrospective review of medical records included all inpatients with serum sodium (sNa)≤128 mmol/l who died at a teaching hospital over a 3-month period. The aim of this study was to examine the clinical course and the pote...

ea0021p51 | Clinical practice/governance and case reports | SFEBES2009

Mass in the median eminence: an unusual cause of confusion

Theodoraki Aikaterini , Bouloux Pierre-Mark , Khoo Bernard

A 45-year-old man was found wandering in the streets by the Ambulance Service. He complained of productive cough with haemoptysis. On examination he was cachectic with clubbing, and he was confused (abbreviated mental test score 1/10). Chest XR showed left hilar and perihilar air space shadowing. He was treated for a community acquired pneumonia. A CT scan of the head showed a mass lesion in the pituitary fossa, confirmed on an MRI scan.Assessment of his...

ea0019p163 | Endocrine tumours and neoplasia | SFEBES2009

Relationships between 24-hour urine calcium:creatinine clearance ratio and fractional excretion of calcium based on fasting morning urine samples

Han CH , Han TS , Bouloux PMG

Aims: To determine the relationships between calcium:creatinine (CaCr) clearance ratio and fractional excretion of calcium (FECa).Design: Ten-week study of 15 patients aged 25–93 years undergoing investigations for parathyroid hormone (PTH)-related hypercalcaemia and 39 healthy volunteers aged 20–61 years.Outcome measures: CaCr clearance ratio calculated from 24-hour urine collection and FECa from 5 ml fasting urine aliqu...

ea0019p168 | Endocrine tumours and neoplasia | SFEBES2009

Short-term and longer-term test-retest reliability of non-fasting calcium:creatinine ratio and fasting fractional excretion of calcium

Han CH , Han TS , Bouloux PMG

Aims: To assess the short-term (one day) and longer-term (10–113 days) test-retest reliability of calcium:creatinine (Ca:Cr) ratio calculated from 24-hour urine collection and its surrogate fractional excretion of calcium (FECa) from urine aliquots.Methods: On the first visit, eight subjects (aged 22–55 years) collected two fasting urine aliquots (5 ml) at the start and end of their non-fasting 24-hour urine collection for FECa<...

ea0015oc11 | Reproduction | SFEBES2008

Identification of a novel compound heterozygous mutation in the gonadotrophin releasing hormone receptor in two siblings with isolated hypogonadotrophic hypogonadism

Chesover A , Kim S , Ahlquist J , Bouloux PNG

Isolated hypogonadotrophic hypogonadism (IHH) is defective secretion of luteinizing hormone (LH) and follicular stimulating hormone (FSH) resulting in incomplete or absent pubertal development and infertility. Several genetic defects underlying IHH have been identified, including in the gonadotrophin releasing hormone receptor (GnRH-R) gene. Here we report a case of two sisters, with clinical phenotypes of IHH, presenting with poor breast development, primary amenorrhoea and a...

ea0015p102 | Clinical practice/governance and case reports | SFEBES2008

An unusual case of vaginal bleeding: a novel deletion in 17βHSD3 resulting in male pseudohermaphroditism

Chesover A , Kim S , Saleh F , Bouloux PNG

17-beta hydroxysteroid dehydrogenase 3 (17βHSD3) converts androstendione to testosterone in the male testis. Testosterone is necessary for the development of the external male genitalia, a failure of which can result in sexual ambiguity.We present a 22-year-old individual presenting with vaginal bleeding on attempted intercourse. At puberty (13–14 years old), being brought up as a girl, she began to virilise alongside minimal breast development...