Searchable abstracts of presentations at key conferences in endocrinology

ea0009p154 | Thyroid | BES2005

Can deacetylation promote radioiodide uptake in thyroid cancer?

Clarke C , Burbridge E , Smyth P

Acetylation of DNA can result in gene silencing. In the thyroid such phenomena can lead to the loss of ability to accumulate radioiodide. The aim of this study was to examine the effects on the rat thyroid cell line FRTL-5 and human thyroid follicular cancer cell line FTC-133 of Trichostatin A (TSA), a histone deactylase inhibitor. A concentration of TSA was selected using MTT cell viability assays for use in uptake, efflux and expression studies. Cells were incubated with TSA...

ea0007p81 | Endocrine tumours and neoplasia | BES2004

Deacetylating agents as mediators of iodide uptake and efflux in thyroid and breast

Clarke C , Burbridge E , Smyth P

Epigenetic phenomena such as methylation or acetylation of DNA can result in transcriptional inactivation and gene silencing. In the thyroid such phenomena can bring about the loss of ability to accumulate iodide as a result of methylation of CpG islands in human sodium iodide symporter (NIS) and Pendrin (PDS) DNA, limiting the ability to utilise radioiodide therapy. This study examines the effects of Trichostatin A (TSA) a histone deacetylase (HDAC) inhibitor on a rat thyroid...

ea0007p237 | Thyroid | BES2004

Seaweed as a model for iodide uptake and retention in the thyroid

Burbridge E , Clarke C , Smyth P

Uptake of ingested iodide (I-) in the thyroid is achieved through an active transport system, the sodium iodide symporter (NIS). The gland has the ability to accumulate I- from the bloodstream by a factor of 20-40. Seaweeds, which in vivo bear the same relationship to seawater, as does the thyroid to the bloodstream, have a dramatically more efficient I- uptake system, accumulating I- from seawater by a factor of anything up to 1 mil...

ea0013p305 | Thyroid | SFEBES2007

Seaweed as a model for iodide accumulation and storage

Cloughley George , Emma Burbridge , Kraan Stefan , Keegan Noel , Smyth PPA

Seaweeds share properties with the mammalian thyroid and other iodide concentrating organs in that they take up iodide from surrounding seawater and internalise it within cells. The previously demonstrated high iodine concentration within seaweeds prompted a study of accumulation and retention of 125I and its location within the plants. Seaweed discs (1 cm3) cut from members of the red, green and brown phyla which were incubated at 4C in seawater spiked w...

ea0011p430 | Endocrine disruptors | ECE2006

Endocrine disorders in thallasaemia – local experience in an inner city hospital in Birmingham, England

Gangopadhyay KK , Das G , Burbridge W , Wright C , De P

Endocrinopathies are amongst the most common complications of thallasaemia, which is a hereditary disorder of haemoglobin synthesis and excessive iron deposition is thought to be the main reason.Our hospital serves a multiethnic population and consequently we see a substantial number of patients with thallasaemia who are screened for endocrine complications. Those found to have endocrine problems are reviewed in our joint thallasaemia-endocrine clinic. B...

ea0009p147 | Thyroid | BES2005

Seaweed - a marine thyroid?

Burbridge E , Smith D , Kraan S , Smyth P

Seaweed consumption results in high levels of iodine intake in Asian populations and influences the presentation of thyroid and perhaps extrathyroidal disorders. The relationship of seawater to seaweed is analogous to that between the bloodstream and the thyroid. However, seaweed has a dramatically more efficient uptake system than the thyroid, concentrating iodide from seawater by a factor of up to 106 compared to 40-50 for the thyroid. The ability of seaweeds to b...

ea0049ep409 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Improving safety in diabetes management and reducing insulin errors in hospital – practically achievable or a utopian fantasy?

Burbridge Wyn , Braycotton Lynne , Puttanna Amar , Yadagiri Mahender , Ilsley Dee , Mukhopadhyay Sagnik , Munichoodappa Karthik , De Parijat

42 insulin related incidents were reported within our Trust in 2014. Subsequent Root Cause Analysis revealed numerous insulin errors, hyperglycemia mismanagement and highlighted significant deficits in diabetes knowledge amongst nursing staff. To address the above issues, new safety interventions were introduced and five key outcomes are:1. A new stand-alone insulin prescription chart introduced May’15 has seen insulin incidents dec...

ea0034p61 | Clinical practice/governance and case reports | SFEBES2014

Endocrine complications of thalassemia and its treatment: a local experience

Deller Serena , Mistry Radhika , Burbridge Wyn , Pancham Shivan , Wright Christine , De Parijat

Introduction: Treatment of β thalassemia major results in excessive iron deposition in most tissues including the endocrine glands.Aim: To find out the prevalence of endocrine complications in our thalassemia-endocrine clinic as set out by the UK thalassemia society guidelines.Methods: Clinic notes and electronic results of all patients attending Birmingham City Hospital for the 2-monthly thalassemia-endocrine MDT clinic (2010...

ea0009p49 | Growth and development | BES2005

Expression of iodide transporters in human placental tissue

Burbridge E , Nawoor Z , Smith D , Sheehan S , O'Herlihy C , Smyth P

Synthesis of thyroid hormones by the fetal thyroid requires the passage of iodide through the placenta. In the thyroid active iodide transport is facilitated by three transporters, the sodium iodide symporter (NIS), Pendrin (PDS) and the recently described the human apical iodide transporter (hAIT). Simultaneous expression of all three transporters appears to be thyroid restricted and although extrathyroidal expression of individual transporters has been reported, relatively l...

ea0048oc4 | Oral Communications | SFEEU2017

One year efficacy, safety and tolerability outcomes of endoscopic proximal intestinal exclusion therapy using the Endobarrier device: institution of the UK’s first National Health Service Endobarrier service for type 2 diabetes and obesity

Gupta Piya Sen , Yadagiri Mahender , Irwin Susan , Burbridge Wyn , Gandhi Hardeep , Alden Rachel , Bleasdale John , Fogden Ed , Anderson Mark , Ryder Bob

Introduction: Our institution leads a UK, multicentre, randomised controlled trial (REVISE-Diabesity ISRCTN00151053) investigating the interaction of Endobarrier therapy, a 60 cm endoscopically implanted proximal intestinal liner, with glucagon-like peptide-1 drug therapy.Aims: To evaluate whether acquired experience could translate into establishment of an effective and safe NHS Endobarrier service in patients with diabesity.Metho...