Endocrine Abstracts

Proteins associated with pregnancy urine and urinary-derived hCG preparations have been associated with stimulation of Candida albicans, induction of apoptosis in Kaposi's sarcoma, and inhibition of HIV replication. The active components have been previously reported to be 18 kDa, 15-30 kDa and 2-4 kDa proteins, and suggested in one study to be a ribonuclease (1).The urinary hCG preparation CG-10 (supplied by Sigma Chemical Company Ltd) is known to be pa...

Precocious pubertal development is generally defined as the clinical manifestation of secondary sex characteristics above the 99.6th centile for age. In the UK this corresponds to 8 years in girls and 9 years in boys. The UK growth charts divide at these ages to remind us that a child who plots on the left sided panel and who has pubertal signs is precocious and warrants medical review. The vertical puberty lines have reminders of precocity (and delay). Stage lines on the RCPC...

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Introduction: Gynaecomastia (GM) is common in boys with Klinefelter syndrome (KS) during adolescence. It develops due to the relatively higher diurnal oestradiol–testosterone ratio in early to mid puberty. The physiological mid-late pubertal rise in testosterone causes the GM to disappear in chromosomally normal boys, but it persists in boys with KS if this rise in testosterone is blunted.Aim: As a previous longitudinal RCT of testosterone in boys w...

Growth through the pubertal progress is notoriously difficult to track and interpreting abnormal patterns is tricky. Current growth charts are unhelpful. I will present new analyses of understanding of growth patterns and the tempo of pubertal changes and how they all link together. The RCPCH has launched a specialist growth chart in June to help identify and diagnose abnormal growth patterns during puberty. These include growth centiles for extremes of stature and weight, and...

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Background: We aim to investigate the influence of GH on pubertal growth in children receiving GH replacement therapy for GH deficiency.Methods: We analyse a large dataset of children (n=236) with GH deficiency from the international KIGS database. We examine the relationship between pubertal growth and treatment with GH replacement therapy using linear regression and repeated measures analysis, and the incremental cost benefit of increasing doses...

Aim: Differentiating idiopathic hypogonadotrophic hypogonadism from extreme maturational delay can be difficult, so most boys receive testosterone (T) replacement until the diagnosis becomes clear. Standard 3 month T therapy for maturational delay does not diminish adult stature, so we set out to determine whether T treatment of greater than 6 months duration would have an adverse effect on final height (FH) in boys with the eventual diagnosis of extreme maturational delay.</p...

Gonadotropin-releasing hormone analogues (GnRHa) are prescribed to adolescents with gender dysphoria under age 15 who have reached Tanner stage 2/3 to prevent progression through puberty and allow them time to consider their gender identity. The possible effects of the therapy on the pubertal growth spurt are poorly understood. A height more congruent with their identified gender is desired by transgender individuals, thus it is crucial that they are fully informed of its pote...

Introduction: Gynaecomastia (GM) is a major contributor to psychological morbidity in adolescent boys, yet there is a lack of evidence for effective treatment. It is known to develop due to the relatively higher diurnal oestradiol–testosterone ratio in early to mid puberty.Aims: We retrospectively looked to identify possible criteria for the selection of patients to predict optimal management of GM. We also examined the effect on the persistence of ...