Endocrine Abstracts

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The androgen receptor (AR) is a major therapeutic target once prostate cancer has progressed. Even invasive cells remain initially responsive to androgen deprivation therapy (ADT) but ultimately become ADT-recurrent, which is lethal. Aggressive ADT-recurrent cells nonetheless retain active AR signaling, but in a distorted form as a result of the actions of transcription factor co-regulators, including the corepressors, for example as revealed by the TCGA consortium. We have ex...

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Over the last 25 years roles have been established for vitamin D receptor (VDR) to influence cell proliferation and differentiation. For example murine knockout approaches have revealed a role for the VDR to govern mammary gland growth and function. These actions appear widespread as the enzymes responsible for 1α25(OH)2D3 generation and degradation, and the VDR itself, are all functionally present in a wide range of epithelial and haematopoietic cel...

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Introduction: We describe a novel case of familial congenital aniridia in a Caucasian woman with associated insulin requiring diabetes mellitus. This human combination has been described in Asian families in association with a heterozygous Paired Box 6 (PAX6) mutation (1) with subsequent evidence supporting that the mutation in this transcription factor causes decreased Proconvertase 1/3 function in the pancreas and a high proinsulin to insulin ratio (2). Our case does not hav...