Endocrine Abstracts

Survival of most species relies on the fact that small populations of endocrine neurons located in the hypothalamus determine critical functions such as reproduction, growth, and metabolism. These neurons are so finely regulated that their functions have been conserved across evolution; nonetheless, the mechanisms underlying these regulatory features remain hazy. Indeed, research efforts have been hindered by the complexity and inaccessibility of the hypothalamic-pituitary sys...

Graves’ disease is one of the multiple autoimmune diseases that have been reported in HIV-infected patients. With the upsurge of highly active anti-retroviral therapy (HAART) the incidence of autoimmune diseases in HIV-infected patients is increasing, especially after immune reconstitution. We present a male, 51-year-old, who started complaining with anxiety, sudoresis and palpitations. The laboratory workout revealed hyperthyroidism: TSH <0.02 μU/ml (0.46–4...

Background: The identification of patients with high risk of diabetes mellitus (DM) after renal transplantation in the pre-transplantation period is crucial for the prevention of this pathology and reduction of the risk of cardiovascular morbidity and mortality. With this study we intended to identify the risk factors for NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/20...

Background: The identification of patients with NODAT in renal transplantation is essential to establish adequate treatment and to reduce cardiovascular risk and graft failure. With this study we intended to evaluate the frequency of NODAT and to characterize patients with NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/2009 and 12/31/2013 were retrospectively evaluated. ...

*These authors contributed equally to this work.BackgroundRegular physical activity has a crucial role in the control of Type 1 Diabetes (T1D). Insecurity in the management of insulin therapy and fear for dysglycemia are barriers to the practice of exercise in T1D.AimTo identify barriers to regular physical activity in adult patients with T1D; to evaluate the impact of two ed...

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

Introduction: Primary hyperparathyroidism results in increased bone resorption. The presence of osteoporosis is at present an established surgery criteria.Objective: The aim of this study was to evaluate the changes in bone mineral density (BMD) after surgery in patients with primary hyperparathyroidism.Material and methods: Retrospective study of 58 patients with primary hyperparathyroidism treated by parathyroidectomy from 2004 t...

Introduction: Childhood-onset hypopituitarism is an uncommon yet increasingly diagnosed disorder. As endocrinologists, we generally deal with the complexities of hormonal replacement and, when required, follow these patients to detect tumor recurrences. However, some causes of childhood- onset-hypopituitarism have comorbidities which can significantly increase morbi-mortality. We present the case of a 21-year-old girl who was diagnosed with ROHHAD syndrome.<p class="abstex...

Background: Thyroid carcinoma is the most common endocrine malignancy. BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid carcinomas (PTC). There are some discrepancies regarding the overall frequency of the mutation, its prevalence in PTC-variants and its relationship with clinicopathological parameters of poor outcome.Aims: To investigate the relationship of clinicopathological features of PTC with BRAF mutation wit...

Thyroid carcinoma is the most common endocrine malignancy. However, the absence of prognostic markers for identified well-differentiated tumors versus undifferentiated/anaplastic or poorly differentiated enhances of the progression of recurrent forms with an unfavorable prognosis. In order to identify potential markers for thyroid cancer prognosis prediction, we analyzed by cDNA micro-array the gene expression profile of tumors of the thyroid, with different degrees of maligna...