Searchable abstracts of presentations at key conferences in endocrinology

ea0011p519 | Endocrine tumours and neoplasia | ECE2006

Radiotherapy and o,p’-DDD induce an inhibition of growth and interfere in the cell cycle in H295-R adrenocortical cell line

Stigliano AS , Cerquetti LC , Bucci BB , Carlini PC , Amendola DA , Misiti SM , Miceli RM , de Paula UDP , Brunetti EB , Toscano VT

Background: Mitotane,(o,p’-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p’-DDD could increase the susceptibility to th...

ea0090p409 | Pituitary and Neuroendocrinology | ECE2023

Inflammatory infiltrate in wild-type and non-wild-type GNAS somatotropinomas

Chiloiro Sabrina , Cicia Martina , Giampietro Antonella , Gessi Marco , Lauretti Liverana , Paolo Mattogno Pier , Carlino Angela , Olivi Alessandro , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura , Doglietto Francesco , Bianchi Antonio

Introduction: Somatotropinomas are benign pituitary tumors with heterogeneous biological and clinical behavior. The tumor microenvironment (TME) is an environment generated by the interaction between tumor cells and the host immune system. It affects both the behavior of the tumor and the outcome of the therapy. The GNAS gene encodes the alpha subunit of G proteins associated with hormone receptors such as TSH, PTH, GHRH, FSH/lH, ACTH. Mutation of this gene has been associated...

ea0090p424 | Pituitary and Neuroendocrinology | ECE2023

The acro-TIME score: a new clinical, pathological and immune integrative approach to early identify acromegaly patients resistant to treatment with first generation somatostatin ligands

Chiloiro Sabrina , Giampietro Antonella , Gessi Marco , Lauretti Liverana , Mattogno Pierpaolo , Costanza Flavia , Carlino Angela , Olivi Alessandro , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura , Doglietto Francesco , Bianchi Antonio

Somatotropinomas are benign pituitary tumors, with a heterogenous biological and clinical behavior. Tumor microenvironment reflects the interaction between tumor cells and the host immune system and may regulate tumor behavior and therapy outcome. We develop a scoring system that includes clinical, pathological and immune markers to early identify fg-SRLs resistant acromegaly pts. 43 acromegaly pts were included according the following criteria (1) first line treatment with su...

ea0029p1200 | Obesity | ICEECE2012

Acute ghrelin effects on depressive-like behavior in bulbectomyced mice: a possible mechanism of action

Carlini V. , Martini A. , Kumar P. , Sawant R. , Rask-Andersen M. , Fredriksson R. , Rubiales de Barioglio S. , Schioth H. , Fiol de Cuneo M.

Ghrelin (Ghr) is an orexigenic peptide investigated by Lutter and col. 2008 for its potential role in the development of depressive symptoms induced by chronic stress, suggesting that Ghr defends against depressive-like symptoms. Rodent bilateral olfactory bulbectomy (OB) is an animal model that appears to fulfill many of the criteria required for the study of depression; hence, Ghr could be an alternative therapeutic tool for depression therapy. We study the possibility that ...

ea0003p118 | Endocrine Tumours and Neoplasia | BES2002

Outcome of transphenoidal surgery by one surgeon for acute acromegaly

Akber M , Clayton R , Carlin W

Objective: Surgical outcome in acute acromegaly has been studied nationally and internationally with conflicting and variable results. Definition of cure varies from centre to centre.Rrecent studies have shown increased mortality in acromegalic patients with GH level >5mu/l. We studied the out come of transphenoidal surgery by a single surgeon at 6 and 12 moths after surgery to compare the results with other national and international published studies.Patients and methods...

ea0011p202 | Clinical practise and governance | ECE2006

Cushing’s disease – an audit of outcomes following pituitary surgery from a single centre

Baskar V , Varugheese G , Carlin V , Clayton RN

We evaluate the short and long-term outcomes following diagnosis and treatment of pituitary dependent Cushing’s disease from a single centre. From 1971, there were 47 patients with proven endogenous cortisol excess, of whom, 43 (92%) had pituitary dependent Cushing’s disease. The median age of this cohort was 38±11years and the majority (77%) were females. 17 patients had primary treatment either with radiotherapy (n=9), bilateral adrenalectomy (n=...

ea0044oc4.1 | Adrenal and Steroids | SFEBES2016

Novel brain biomarkers of cognitive abnormalities identified in patients with congenital adrenal hyperplasia

Webb Emma A , Elliott Lucy , Carlin Dominic , Hall Kirsty , Barrett Timothy , Salwani Vijay , Arlt Wiebke , Krone Nils , Peet Andrew , Wood Amanda

Background: Management of patients with CAH remains challenging. There is increasing evidence to suggest that failure to optimize treatment during childhood not only affects final height but also leads to psychological and psychiatric problems. Previous qualitative structural T2-weighted MRI studies have identified white matter hyper-intensities in up to 46% of CAH patients. The nature and functional relevance of these abnormalities remains unknown.Objec...

ea0045oc5.2 | Oral Communications 5- Endocrine | BSPED2016

Functionally significant reductions in white matter in patients with congenital adrenal hyperplasia

Webb Emma , Elliott Lucy , Carlin Dominic , Wilson Martin , Hall Kirsty , Barrett Timothy , Salwani Vijay , Arlt Wiebke , Krone Nils , Peet Andrew , Wood Amanda

Background: Management of patients with CAH remains challenging. There is increasing evidence to suggest that failure to optimize treatment during childhood not only affects final height but also leads to psychological and psychiatric problems, reflecting an underlying effect on neural development. Previous qualitative structural T2-weighted MRI studies have identified white matter hyper-intensities in up to 46% of CAH patients. The nature and functional relevance of these abn...