Endocrine Abstracts

Recent data indicate that steroid action can be completed through genomic (late) and non-genomic (rapid) mechanisms. Non-genomic androgen effects are initiated at the membrane level and imply specific secretory and signaling mechanisms different from the classical intracellular androgen receptor activation. In previous work we have reported that androgen membrane binding sites (Ambs) are present in LNCaP human prostate cancer cells. Their activation mediates a FAK/PI3K/Cdc42/R...