Endocrine Abstracts

Thyroid cancer is the most common endocrine malignancy. It is known that cancer progression involve dysregulation of growth factors (FGFs) and their receptors (FGFRs) have been identified. In thyroid tumors. In particular, FGFR1 and FGFR3 are expressed in most well differenziated tumors, FGFR4 is predominantly expressed in aggressive tumor types and cells lines, while FGFR2 is the only receptor consistently detected in normal human thyroid tissue and its expression is downmodu...

Radioiodine-131 is commonly used for treatment of hyperthyroidism, however the effects on testis function are not known. This prompted us to study testis function in hyperthyroid men after 131I treatment. 15 hyperthyroid patients scheduled for 131I treatment underwent: testis US, hormone assessment and sperm analysis before and 45 days, 3, 6 and 10–15 months after 131I. The control group (for testis volume and semen analysis) was constitut...

Congenital hypothyroidism (CH) with a normal located thyroid gland may be transient or permanent and environmental, iatrogenic, immunologic or genetic factors can be involved. PAX-8, TSH receptor and THOX2 gene mutations have been identified in cases of CH with a gland of normal size.In this study we performed genetic analysis of PAX8, TSH receptor and THOX2 genes in 14 children with CH and a normal sized eutopic gland. Genomic DNA was extracted from lym...