Endocrine Abstracts

While organisms have evolved to maintain the fidelity of their genome, the epigenome, in contrast, is inherently plastic, with extensive remodeling required during normal development. This epigenomic plasticity plays a role in preparing the developing organism for its adult environment. The epigenome is able to sense environmental cues, providing an opportunity for adaptive changes during development that can provide a later-life survival advantage. However, epigenomic plastic...

Background: Post traumatic Hypopituitarism (PTHP) is common, its prevalence is about 30%.Aim: The aim is firstly to assess the frequency and predictive factors of hypopituitarism 3 and 12 months following Brain injury (BI) in a simple of 133 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers. Secondly is to evaluate the quality of life and neurocognitive status of this cohort.Method: Hypopituit...

Background: Biological diagnosis of adrenal insufficiency (AI) is very difficult in the setting of critical illness like in traumatic brain injury (TBI), and the cut off defining AI need more precision.Aim: The aim is to assess the frequency and predictive factors of AI in a simple of 277 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers.Method: Between November 2009 and December 2013, 277 pat...

Aim: The sex hormones initiate profound physical and physiological changes during early puberty, but to what extent are they responsible for continuing the body composition changes of late adolescence? We aimed to examine the effect on body composition of sudden sex hormone withdrawal to gain insight into their action.Patients and Methods: Thirty six healthy phenotypically and chromosomally normal postpubertal individuals aged 15–17 years with gende...

Introduction: Recently, the factory calibrated FreeStyle Libre (FSL) flash glucose monitoring system has been introduced for use in patients with diabetes mellitus. We assessed the accuracy of FSL compared to the finger prick capillary blood glucose (CBG) over a 2 week period in patients with congenital hyperinsulinism (CHI) and assessed the parents’ experience of using FSL.Methods: About 346 episodes of CBG along with corresponding swipe FSL readin...

IntroductionDiabetic nephropathy is the leading cause of end-stage-kidney disease (ESKD). Clinical practice guidelines recommend prescribing renin–angiotensin aldosterone system inhibitors (RAASi) to prevent diabetic nephropathy at any stage. We conducted this extensive meta-analysis to compare the effects of RAASi with placebo and other antihypertensives in adults with diabetes on binary and continuous renal outcomes to provide a comprehensive revi...

Background: Glucagon-like peptide 1 (GLP-1) is an incretin hormone released from enteroendocrine L-cells in the gut. GLP-1 analogues and dipeptidyl-peptidase-4 inhibitors are currently used to treat type-2 diabetes. A greater understanding of the mechanisms underlying the release of GLP-1 may facilitate the development of therapeutics to stimulate the release of endogenous GLP-1. Bile acids have been shown to induce GLP-1 release via the G protein-coupled bile acid receptor 1 ...

Journal of Endocrinology 2013 219 51–58. DOI: 10.1530/JOE-13-0167...

Background: Hypophosphatasia (HPP) is a rare, inherited metabolic disease caused by deficient activity of tissue nonspecific alkaline phosphatase (TNSALP).Methods: Baseline/pretreatment data from the Global HPP Registry were analyzed to compare HPP disease burden between adults (≥18 years of age) with skeletal manifestations (history of rickets, biopsy-proven osteomalacia, recurrent or poorly healing fractures/pseudofractures, etc; Skeletal group) ...

Quality of life is impaired in patients who have suffered Cushing’s syndrome (CS).Aim: Evaluate QoL with the new questionnaire CushingQoL in Spanish patients in a clinical practice setting and compare it with a generic QoL questionnaire, EuroQoL-5 Dimensions (5D) and its Visual Analogue Scale (VAS).Patients and methods: Forty-three patients with CS (38 pituitary-dependent, 28 cured) were approached during their regular endocri...