Endocrine Abstracts

Jens Sandahl Christiansen, Medical Department M, Aarhus University Hospital, Aarhus, Denmark AbstractJens Sandahl Christiansen, MD, is professor of medicine and consultant endocrinologist at Aarhus University Hospital, Kommunehospitalet, Aarhus, Denmark. He graduated from Copenhagen University Medical School, and has been trained in diabetes and endocrinology in Copenhagen and Aarhus.Dr. Chr...

Long-lasting and/or delayed reproductive effects of developmental exposure to mixtures of environmental chemicals were investigated in rats. Wistar rats were exposed to mixtures of estrogenic or anti-androgenic endocrine disrupters in pregnancy and lactation, and effects in offspring at 12–18 months of age were studied. The mixture included 13 estrogenic and anti-androgenic chemicals, including phthalates, pesticides, u.v.-filters, bisphenol A, butylparaben and paracetamo...

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Growth hormone (GH) is secreted throughout life - albeit in diminishing quantities with age. Its many different physiological actions have been known since the classical work of Maurice Raben in the late fifties. However, due to lack of the hormone, replacement therapy was for many years restricted to the pediatric treatment of growth disorder, and its place in medicine became tightly connected with growth, and growth alone. Since the mid eighties natural sequence GH have been...

Open access publishing provides authors with the highest possible visibility for their work, as articles are made freely available online to everyone. Many funding bodies and institutions around the world are adopting policies, which require their researchers to publish their work open access. Do you know how open access policies affect you, and how to comply? This talk will clarify what open access publishing means, including the difference between green and gold open access ...

The Management of both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) involves careful monitoring and treatment of hypertension, hyperlipidaemia and hyperglycaemia. Aggressive treatment of high blood pressure and high cholesterol has been proven effective in reducing mortality in both T1DM and T2DM. Various guidelines advocate certain values for blood pressure and for cholesterol to be aimed for. These cut-off values have been pushed downwards constantly during the last 3 d...

The clinical syndrome associated with profound growth hormone deficiency (GHD) in adults has now been established and recognised for more than ten years. The multiple physiological and metabolic actions of growth hormone (GH) has been shown in a logical way to translate into recognisable symptoms and signs in individuals lacking the hormone. Normalization of abnormal physiological and metabolic parameters secondary to GH-replacement therapy has been demonstrated beyond reasona...

Introduction: Radioiodine (RAI)-therapy for Graves’ disease (GD) is often followed by worsening autoimmunity, and the increase in TRAb may persist for several years. In pregnant women TRAb pass the placenta and may stimulate the fetal TSH receptor with a risk of fetal and neonatal hyperthyroidism.Case report: A 21-year old woman with GD was treated with RAI, and subsequently was euthyroid with L-T4-replacement. Before RAI-therapy, TRAb was 8 U/l (re...

Background: Several studies have documented an altered body composition in Turner syndrome (TS), a model of premature ovarian failure. Body fat is increased and muscle mass is decreased. The ovarian failure necessitates substitution with female hormone replacement therapy (HRT) for a number of years, and HRT induces favourable changes in body composition with a decrease in body fat and an increase in fat free mass. It is unknown how HRT affects protein metabolism.<p class=...

Female adrenal failure involves impaired DHEA secretion and very low circulating androgens. To address the impact of a daily physiological substitution dose of capsule DHEA 50 mg on quality of life and sexual parameters, we performed a 6 month trial in a randomised, crossover and placebo controlled design. The trial was approved by the local ethical committee and conducted according to GCP guidelines. Ten patients were enrolled. Seven patients reported seborrhoic side effects ...