Endocrine Abstracts

Recent integrative approaches showed that adipose tissue play a major endocrine role. Molecules secreted by the expanding adipose tissue modulate systemic inflammation and contribute heavily to the pathology of obesity co-morbidities. Acylation stimulating protein (ASP) is an adipokine that has been linked with energy metabolism and lipid metabolism. The ASP receptor, C5L2, is widespread within tissues in the organism, yet ASP effects outside the adipose tissue remain explored...

Background: Adiponectin is an adipocyte-derived adipokine, down-regulated in obesity linked disorders. Here, we investigated the genotypic variability of adiponectin (at position; +T45G and +G276T) and its association with circulating adiponectin and metabolic syndrome in North Indian adult women.Methods: We compared metabolic syndrome (MetS; 269) women to without metabolic syndrome (wMetS; 272) women of North India. Genotype frequencies of the adiponect...

Background: The central component of the complement system, C3, is associated with obesity, type 2 diabetes and cardiovascular disease however the underlying reasons are unknown. In the present study we evaluated gene expression of C3, the cleavage product C3a and its cognate receptor C3aR in subcutaneous and omental adipose tissue in women.Methods: Women (n=140, 21–69 years, BMI 19.5–79 kg/m2) were evaluated for anthropomet...

Objective: Acylation Simulating Protein (ASP) has been shown to regulate lipid clearance and glucose uptake in adipose tissue. In vitro studies demonstrate that insulin stimulates ASP secretion from adipocytes. Individuals with obesity and/or metabolic disturbances (insulin resistance and type 2 diabetes) have increased plasma ASP, suggesting ASP resistance. Therefore, the present study evaluates whether ASP levels are influenced by the metabolic profile of overweight and obes...

Recently, several groups have described a subset of obese women, who despite having excessive total body fat, are insulin sensitive (ISO for Insulin Sensitive Obese), normotensive and present a favorable lipid profile. Adiponectin, ghrelin and leptin play important roles in the regulation of energy metabolism and food intake. Moreover, all three hormones have been reported to be closely linked to insulin resistance and regulated by insulin. Therefore, we propose to investigate...