Searchable abstracts of presentations at key conferences in endocrinology

ea0021pl8biog | Clinical Endocrinology Trust Lecture | SFEBES2009

Clinical Endocrinology Trust Lecture

Clayton P E

P E Clayton, Endocrinology and Diabetes Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK AbstractPeter Clayton is Professor of Child Health and Paediatric Endocrinology in the Faculty of Medical and Human Sciences at the University of Manchester. He is an honorary consultant at the Royal Manchester Children’s Hospital and at the Christie Hospital and is the Director of t...

ea0058oc4.2 | Oral Communications 4 | BSPED2018

Gene expression signatures in children with growth hormone deficiency (GHD) and Turner syndrome (TS) predict response to growth hormone

Clayton Peter , Stevens Adam , Murray Philip , Garner Terence

Background: Recombinant human growth hormone (r-hGH) is the primary therapeutic agent for disorders of growth including growth hormone deficiency (GHD) and Turner syndrome (TS). There is a high cost associated with treatment and existing methods to predict response (and hence alter management) can only account for 40–60% of the variance.Methods: GHD (n=71) and TS patients (n=43) were recruited as part of a study (PREDICT) on the lo...

ea0034p164 | Growth and development | SFEBES2014

Distinct gene expression is associated with epigenetic and growth-related network modules in relation to gender differences in the timing of the pubertal growth spurt

De Leonibus Chiara , Chatelain Pierre , Clayton Peter , Stevens Adam

Background: The return to active long bone growth in puberty is a distinctly human event1 and occurs ~2 years earlier in girls compared to boys. Evolutionarily conserved networks of genes are associated with the developmental phases of childhood in multiple tissues2, implying the existence of a genetic program that controls the pubertal return to growth.Objectives: To identify biological functions associated with gender and age-rela...

ea0025mte1 | (1) | SFEBES2011

Abnormal growth and puberty presenting in late adolescence

Clayton Peter

Young people in their late teenage years may present to either paediatric or adult endocrine clinics with abnormal growth (usually as short stature and/or recognition of slowing growth) and delayed or absent puberty. Anxieties about growth potential may be very significant, and the lack of puberty may blight social interactions and markedly reduce self-esteem.Although constitutional delay in growth and puberty is the most common diagnosis for this type o...

ea0016s15.4 | GH treatment of syndromic short stature - facts and myths | ECE2008

Consensus on GH Treatment in SGA

Clayton Peter

In 2006, the International Paediatric Endocrine Societies and the GH Research Society convened a meeting to consider the management of the SGA child through to adulthood. This included consideration of strategies for management of the short SGA child who has failed to show catch-up growth. The following statements relate to the outcomes of this meeting.Short children born SGA form a heterogeneous group with various aetiologies and treatment should be pre...

ea0015s55 | Transitional endocrinology | SFEBES2008

The management of congenital adrenal hyperplasia from paediatric to adult care

Clayton P

Congenital adrenal hyperplasia (CAH) is a life-time disorder affecting 1 in 10 000–15 000 infants and in 90–95% of cases is due to a reduction in the activity of the adrenal 21-hydroxylase enzyme. CAH is frequently diagnosed in the newborn period with virilisation of the genitalia in females and salt-wasting (SW) in both sexes, the latter associated with very low levels of 21-hydroxylase enzyme activity. The simple virilising (SV) form presents during childhood with ...

ea0012s23 | Sexual differentiation | SFE2006

Management of disorders of sex development

Clayton PE

Disorders of sex development (DSD, previously termed intersex disorders) embrace a broad range of pathologies encompassing the undervirilised male, the virilised female, true hermaphroditism (defined by the presence of ovotestes) and sex reversal (e.g. 46XX male). For those infants born with genital abnormalities that make immediate gender assignment not possible, there is an urgent need for specialist input to achieve a diagnosis and develop a management plan. The DSD team wi...

ea0044p169 | Neuroendocrinology and pituitary | SFEBES2016

Significance of cumulative GH exposure in patients with acromegaly: comparison between patients in whom control was achieved and patients with active disease

Varadhan Lakshminarayanan , Clayton Richard

Aim: The aim of the study was to assess the differences between patients in remission in acromegaly and those with active ongoing disease, using cumulative GH measurement as risk factor for various complications.Methods: A retrospective observational analysis of all patients with acromegaly treated at a tertiary referral centre since the initiation of service (~50 years) was conducted. Cumulative GH exposure was calculated as a sum of averages of GH leve...

ea0041ep286 | Clinical case reports - Pituitary/Adrenal | ECE2016

Successful management of a case of cerebral salt wanting syndrome (CSWS) related hyponatremia

Yahia Seifeldin , Clayton Jennifer

43-year-old lady with a history of rheumatoid arthritis (On Sulfasalazine and Infliximab IV every 8/52), was brought in to our hospital following a collapse. She had had acute onset of headache 6 weeks prior to admission with nausea, vomiting and blurred vision but her symptoms had gradually resolved. Her GCS on arrival was 5. Subsequent CT scan brain showed acute right-sided subdural haematoma and subarachnoid haemorrhage and was indicative of coning. She was taken to theatre...