Endocrine Abstracts

Malignancy is the most common cause of hypercalcaemia. Hypercalcaemia in solid tumours involves the secretion of humoral factors by tumour cells that act systemically on target organs (bone, kidney) to alter calcium homeostasis. Parathyroid hormone-related protein (PTHrP) is a major humoral factor. It is produced by a variety of solid tumours and acts on PTH receptors to cause increased calcium reabsorption from renal tubules and increased bone resorption. Other humoral tumour...