Endocrine Abstracts

Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition which leads to glucocorticoid deficiency. During childhood, aims of treatment are to prevent adrenal crisis and to achieve optimal adult height and normal puberty. In adults, aims of treatment are to prevent adrenal crisis, ensure normal fertility and avoid long-term consequences of glucocorticoid use. Current regimens with glucocorticoids cannot optimally replicate the normal physiological cortisol level...

Objective: To investigate the long term outcomes for patients with endogenous subclinical hyperthyroidism (SH).Design: Population record-linkage technology was used retrospectively to identify patients with SH and hospital admissions from January 1, 1993 to December 31, 2009.Patients: All residents over 18 years old with at least two serum TSH measurements below the reference range for at least 4 months apart and normal free T...

Objective: To define the rates of progression to frank hyperthyroidism and to normal thyroid function for subclinical hyperthyroid patients (SH).Design: Record-linkage technology was used retrospectively to identify patients with SH in the general population from 1st January 1993 to 31st December 2009.Patients: All residents over 18 years old with at least two measurements of TSH below the reference range for at least 4 months from...

Background: Adrenal incidental masses (incidentalomas) are present in up to 10% of patients. The majority of these adrenal masses are clinically inapparent, but may be functionally active in a significant proportion; thus assessment by endocrinologists is essential.We assessed the functionality of adrenal incidentalomas referred to the endocrinology team at the Queen Elizabeth Hospital in Gateshead.Methods: Patients with adrenal in...

IntroductionAntithyroid drugs are widely used in the therapy of hyperthyroidism. This review (update of Cochrane review: Antithyroid drug regimen for treating Graves' hyperthyroidism. In: The Cochrane Library, Issue 4, 2003; with 4 additional trials) assesses the effects of dose, regimen and duration of antithyroid drug therapy for Graves' hyperthyroidism.MethodsThe Cochrane Controlled Trials Register, MEDLIN...

Introduction: The relation of hypothyroidism with the breast cancer is described early in the literature based in some common pathophysiological paths which associate thyroid gland and breast tissue.Methods: A literature research in PubMed and Cochrane library database was performed for articles studying any possible association between the risk for development of breast cancer with the presence of hypothyroidism history in women.R...

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD).Objective: To review the existing evidence on the effects of different pharmacological interventions on lipid profiles of women with PCOS.Data sources: We searched PubMed, MEDLINE, Scopus,...

Background: Type 2 Diabetes Mellitus is the more prevalent type, caused by a combination of insulin resistance and inadequate insulin response to hyperglycemia1. Aside from pharmacologic interventions, medical nutrition therapy is an integral part of the management of patients with Type 2 Diabetes Mellitus. Whey protein, which is one of the best protein sources, has been investigated for its applicability in improving glycemic control in patients with Type 2 Diabetes Mellitus....

Background: Postsurgical hypocalcemia is the most common and most troubling long-term consequence of thyroidectomy. In this study, we investigated the potential role of routine calcium or vitamin D supplementation in preventing postsurgical hypoparathyroidism.Methods: We carried out a systematic search of MEDLINE and EMBASE for English-language publications using the keywords “calcium”, “vitamin D”, and “thyroid cancer&#8221...

Background: According to the 6th National Nutrition Health Survey, the Filipino is generally unfit, with increasing incidences of major risk factors for cardiovascular disease like hypertension, abnormal lipid profile, obesity and diabetes over the last 5 years. Orlistat, a lipase inhibitor is one of the medications used to facilitate weight loss in obese patients. Given that weight loss is known to be associated with an improvement in the serum lipid profile, concurrent impro...