Searchable abstracts of presentations at key conferences in endocrinology

ea0055p03 | Poster Presentations | SFEEU2018

Non-functional duodenal neuroendocrine carcinoma- a rare cause of diabetes mellitus

Bisambar Chad , Collier Andrew , Duthie Fraser

Case history: We present a 40 year old female admitted with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1 month period. She had no night sweats or change in bowel habit. There was no personal or family history of malignancy or diabetes mellitus. She denied any alcohol, cigarette or illicit drug use. She took no prescription or OTC medication. On examination, she was jaundiced with pale mucous membranes. The rest of systemic examination was normal. Capil...

ea0011p145 | Clinical case reports | ECE2006

Postmenopausal androgen excess: a clinical perspective

Ritchie SA , Collier A , McIntyre M , Connell JMC

We present two cases of postmenopausal, gonadotrophin-dependent androgen excess.Case 1: A 59-year-old postmenopausal female presented with a 4-year history of hirsuitism and male pattern balding. Past medical history included Type II diabetes, hypertension, and polycystic ovarian syndrome. Investigations revealed androgen excess (testosterone 8.9 nmol/l [ref range<2.5], free androgen index 31.8 [ref 0-7], androstenedione 13.7 nmol/l [ref<6.8], DH...

ea0056p145 | Neuroendocrinology | ECE2018

Non-functional duodenal neuroendocrine carcinoma- a rare cause of diabetes mellitus

Bisambar Chad , Collier Andrew , Duthie Fraser

Case history: We present a 40 year old female admitted with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1 month period. She had no night sweats or change in bowel habit. There was no personal or family history of malignancy or diabetes mellitus. She denied any alcohol, cigarette or illicit drug use. She took no prescription or OTC medication. On examination, she was jaundiced with pale mucous membranes. The rest of systemic examination was normal. Capil...

ea0059ep78 | Neuroendocrinology and pituitary | SFEBES2018

Gigantism due to two different causes in the same family – AIP mutation-positive acromegaly and Marfan syndrome

Marques Pedro , Collier David , Barkan Ariel , Korbonits Marta

Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations are responsible for 30% of pituitary gigantism cases. However, pathological accelerated growth and/or tall stature can be unrelated to the growth hormone (GH) axis, and may occur in isolation or as part of a syndrome, such as in Klinefelter, Marfan or Sotos syndromes. We report a five-generation kindred with two brothers with pituitary gigantism due to AIP mutation-positive GH-secreting pi...

ea0020htc2 | Hot topics: Clinical | ECE2009

Primary hyperparathyroidism (Nationwide cohort study): an increased risk of cancer and decreased survival

Ghosh Sujoy , Collier Andrew , Clark David , Elhadd Tarik , Malik Iqbal

Introduction: The incidence of primary hyperparathyroidism (PHPT) is ~3.5/100 000 per yearThe incidence is on the rise due to increase in ‘routine biochemical testing’Has been thought to be a ‘relatively harmless’ disorder.Some patients tend to undergo surgery, while others are conservatively treated and most followed up for a short period before discharge from follow up.Aims:<l...

ea0019oc26 | Bone and Calcium | SFEBES2009

Primary hyperparathyroidism (Nationwide Cohort Study): an increased risk of cancer and decreased survival

Ghosh S , Collier A , Clark D , Elhadd T , Malik I

Introduction: • The incidence of primary hyperparathyroidism (PHPT) in Scotland is approximately 3.5/100 000 per year.• The incidence is probably on the rise due to increase in ‘routine biochemical testing’• Some patients tend to undergo surgery, while others are conservatively treated and most followed up for a short period before discharge from follow up.Aims: • Determine if ri...

ea0004p49 | Endocrine tumours and neoplasia | SFE2002

Pituitary surgery for Cushing's should be carried out by a specialised neurosurgeon

Collier K , Mendoza N , Barakat M , Todd J , Meeran K

Transphenoidal hypophysectomy is often carried out to remove ACTH-secreting tumours of the pituitary. A postoperative serum cortisol of <50nmol/l usually indicates cure of the disease but after other audits found persistent cases, 'remission' is thought to be a more appropriate term.Charing Cross Hospital is the tertiary neurosurgical centre for West London where a single, dedicated pituitary surgeon was appointed in 1995. We analysed the success of e...

ea0077p234 | Reproductive Endocrinology | SFEBES2021

Reproductive health disturbance in the era of the COVID-19 pandemic

Maher Michelle , Keeffe Aedin O’ , Phelan Niamh , Ann Behan Lucy , Collier Sonya , Hevey David , Owens Lisa

Background: The combined effect of the COVID-19 pandemic and associated restrictions have adversely affected population mental health. Periods of psychological distress can induce menstrual dysfunction. We previously demonstrated a significant disruption in women’s reproductive health during the first 6 months of the pandemic. The present study investigates longer term reproductive and mental health disturbances.Materials and Methods: An online surv...

ea0086p120 | Reproductive Endocrinology | SFEBES2022

Female reproductive health disturbance associated with the COVID-19 pandemic persists despite improving mental health- a longitudinal observational study

Lonergan Eibhlin , Maher Michelle , Collier Sonya , Ann Behan Lucy , Phelan Niamh , Hevey David , Owens Lisa

Background: The COVID-19 pandemic has adversely affected population mental health. In April 2021 we conducted an observational study which demonstrated disruption in women’s reproductive and mental health during the first year of the pandemic. Our objective therefore was to perform follow up studies in this cohort of women at 6-monthly intervals, to assess the longer term enduring impact of the pandemic on reproductive and mental health.Materials/Me...

ea0019p342 | Thyroid | SFEBES2009

‘Help! I Can’t Walk’: a case of thyrotoxic hypokalaemic periodic paralysis

Collier Nicholas , Jones Katy , Murtagh Kevin , Seetho Ian , Dean Toby , Maksoud Hisham

Case: A fit strong 26-year-old Caucasian male presented with recurrent falls. He attended the accident and emergency department with a three-month history of episodic weakness of the lower limbs. There was no previous history of medical problems and he was not on medication. On admission a full neurological examination was normal except for reduced power in the lower limbs. He had a raised creatinine kinase 472 U/l (0–170). Potassium was 3.8 mmol/l (3.5–5.3). He was ...