Endocrine Abstracts

Background: Management of diabetes in patients with End Stage Renal Failure (ESRF) is complex, requiring intervention from multiple disciplines. The Joint British Diabetes Societies and Renal Association published the first ever guidelines for the management of patients with diabetes undergoing haemodialysis for ESRF in 2017.Aims and objectives: Assess Current Care Pathways of all patients with Diabetes undergoing Haemodialysis in Cork University Hospita...

The management of children and young people (CYP) with diabetes is forever evolving, with tools and management strategies becoming much more intense. Year on year this has led to an overwhelming burden of educating schools when providing training for over 300 patients with type 1, type 2 and rarer types of diabetes. Children spend on average 1,267.5 hours per year in school – it is essential children’s diabetes management is optimised during this time, and health car...

Introduction: The COVID-19 pandemic prevented face-to-face school diabetes training in 2020/2021 at Birmingham Women’s and Children’s Hospital. Moving school training online was the only viable option to ensure children with type 1 diabetes could attend school.Objectives: 1. Develop an online school training package with competency assessment for all diabetes devices 2. Audit the number of staff competent and the cost and acceptability of the t...

Endometrial cancer is the most common gynaeological malignancy in the developed world: lifetime exposure to oestrogen is a key risk factor. Oestrogen action is mediated by ligand activated receptors encoded by the ESR1 (ERα) and ESR2 (ERß) genes: ERα plays a key role in regulating endometrial cell proliferation. ERß5, is a truncated variant isoform of ERß formed by alternative splicing of ESR2 that contains a DNA binding doma...

Background: Radioiodine is a safe and effective treatment for Graves’ disease. Iatrogenic hypothyroidism is very common after treatment, but its onset is unpredictable. Even a short episode of hypothyroidism can result in significant morbidity and ideally should be avoided. In our centre a standard dose of radioiodine (400 MBq) is used, but for historical reasons two different protocols are used after radioiodine: Regimen A: regular clinical and biochemical monitoring and...

Exogenous glucocorticoids lead to suppression of the HPA axis via negative feedback on the hypothalamus and pituitary and may be associated with increased morbidity and mortality (Wei L. Ann Intern Med. 2004). Many patients whose steroids are no longer required for their underlying disease find withdrawal challenging. Presentations: Case 1: 68-year old male treated with steroids for hepatic graft versus host disease following a stem cell transplant for EBV-lymphoproliferative ...

Spermatogenesis is a complex process that requires the formation of junctional complexes between somatic Sertoli cells and germ cells and hormonal regulation of the Sertoli cells. Androgens and oestrogens are both synthesised in the testis. In adults Sertoli cells contain both androgen receptor (AR) and oestrogen receptor beta (ERß). In the present study we used a transformed Sc cell line (SK11) that was prepared from the testes of mice expressing the large T antigen. Whe...

The HLA and CTLA-4 gene regions, on chromosomes 6p21 and 2q33 respectively, have been consistently associated with Graves' disease (GD). Recent data indicate that both DRB1 (in the HLA class II region) and the 3' untranslated region of the CTLA-4 gene are the most likely regions harbouring the aetiological variants for susceptibility to GD. It is not known, however, whether these variants lead to expression of specific sub-phenotypes in subjects with GD, or contribute to disea...

The autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis (HT), are thought to be caused by complex interactions between genetic and environmental factors, which result in an organ-specific autoimmune response being directed against the thyroid gland. GD and HT, although clinically distinct, share many immunological and histological features. Several potential susceptibility genes for AITD have been investigated, although to date only the HLA an...

Objective : To determine whether simultaneous ultrasonography at the time of scintigraphy affects the diagnosis or diagnostic confidence in patients with hyperthyroidism.Method Used: A retrospective study was carried out involving 100 patients who attended for investigation of hyperthyroidism between 01/07/01 and 31/03/02. All patients ( 15 male, 85 female) had simultaneous radioisotope scanning and ultrasound of their thyroid glands performed and reported. Subsequently th...