Searchable abstracts of presentations at key conferences in endocrinology

ea0011p137 | Clinical case reports | ECE2006

Difficulty to distinguish hyperandrogenia due to a tumoral formation or to polycystic ovary syndrome: a case report

Teissier MP , Combes C , Drutel A , Lopez S

A 24-year-old woman complained about secondary amenorrhoea after stopping oral contraceptive whereas she wanted to be pregnant. Physical examination showed an android obesity with a non-progressive but major hirsutism. Endocrinological investigations eliminated pregnancy but revealed on different samples a high plasma testosterone level (from 2.15 to 2.77 ng/ml), in the tumoral range whereas DHEA-sulfate, delta4-androstendione, sex binding protein and prolactine were normal. S...

ea0011p147 | Clinical case reports | ECE2006

Psycho-biological correlates of free-floating anxiety symptoms in male patients with sexual dysfunctions

Combes J , Chabroux S , Ory JP

Introduction and objectives: Anxiety has a relevant impact on everyday life, including sexual life, and therefore is considered the final common pathway by which social, psychological and biological stressors negatively affect sexual functioning. The aim of this study is to define the psycho-biological correlates of free-floating anxiety in a large sample of patients complaining erectile dysfunction (ED) based sexual problems.Methods: We studied a consec...

ea0039oc5.8 | Oral Communications 5 | BSPED2015

Neonatal TSH: is it useful and appropriate as an indicator of iodine insufficiency in the UK?

Sharif Sahar , Jones Jeremy , Smith Sarah , Combet Emilie

Introduction: The World Health Organisation (WHO) states that in an iodine sufficient population <3% of neonatal TSH values will exceed 5 mU/l. In Belgium and Wales 2.6 and 1.5% of values were above 5 mU/l respectively.Methods: Neonatal TSH (neoTSH) levels (AutoDELFIA fluoroimmunoassay, 2006–2013, Scotland) were analysed for prevalence of high value according to cut-off, season and feeding mode (IBM SPSS 22).Results: Out o...

ea0011p508 | Endocrine tumours and neoplasia | ECE2006

Cushing’s paraneoplastic syndrome secondary to recurrent ovarian carcinoma

Combes J , Chabroux S , Debieuvre D , Ory JP

Obesity is a major cause of chronic hypoventilation and/or obstructive sleep apnea syndrome (OSAS). Aim of this study was to evaluate the prevalence of pulmonary dysfunction and the relationship between OSAS and several clinical, functional and polysomnographics parameters in severely obese patients. 101 subjects (68 females and 33 males) aged 49.2±13.2 years (mean±S.D.), with BMI 46.8±6.5 Kg/m2 were enrolled. Sleep quality and daytime ...

ea0011p624 | Neuroendocrinology and behaviour | ECE2006

Interest of a single treatment by somatostatin analogues in a macroadenoma secreting TSH and GH

Lopez S , Combes C , Drutel A , Archambeaud Mouveroux F , Teissier MP

We report a case of a 69-years-old woman who complained about progressive tachycardia, sweat and flush. Her single background was a breast cancer five years ago which was considered in remission. A first blood sample analysis showed an elevated rate of T4 whereas TSH was normal. An IgF1 assay was realised because of an acromegalic appearance and was abnormally high for sex and age. Further biological investigations confirmed central hyperthyroidism and acromegalia. Alpha subun...

ea0063gp162 | Cushing's | ECE2019

Pharmacokinetics of osilodrostat following single and multiple doses of osilodrostat in healthy subjects and patients with Cushing’s disease

Han Kevin , Tauchmanova Libuse , Atkinson Susan , Darstein Christelle , Zhang Xinrui , Combes Francois Pierre , Pedroncelli Alberto M

Introduction: Osilodrostat is a potent oral 11β-hydroxylase inhibitor currently in Phase III clinical development for the treatment of Cushing’s syndrome (CS). The key pharmacokinetic (PK) properties, drug–drug interactions (DDIs), and population PK findings for osilodrostat in humans are summarized.Methods: Osilodrostat PK has been characterized in nine Phase I studies (healthy subjects and subjects with hepatic or renal impairment), two ...

ea0039ep122 | Thyroid | BSPED2015

Scottish mothers and babies at Yorkhill (MABY) thyroid health study – preliminary report

Cizmecioglu Filiz Mine , Bouga Maira , Fletcher Suzanne , Sharif Sahar , Velasquez Guisella , Blaise Sarah , Jones Jeremy H , Donaldson Malcolm , Combet Emilie

Introduction: Iodine is essential for thyroid hormones synthesis, and fetal/infant neurodevelopment. There is increasing evidence of iodine insufficiency among British women. The MABY study is a longitudinal cohort study assessing the iodine and thyroid status of pregnant women and their offspring.Methods: Healthy women were recruited (target 697 mother/infant pairs) from antenatal clinics at gestational week (GW) 28±1. Blood and urine were collecte...

ea0063p734 | Pituitary and Neuroendocrinology 2 | ECE2019

A phase 2 study assessing osilodrostat in children and adolescent patients with Cushing’s disease – Rationale and methods

Storr Helen L , Shah Nalini , Wojna Judi , Han Kevin , Roughton Michael , Pierre Combes Francois , Pultar Philippe , Savage Martin O

Background: In children, Cushing’s disease (CD) presents with a combination of weight gain and slowed linear growth. First-line pituitary surgery is the treatment of choice for most patients. In paediatric patients, the transsphenoidal surgical success rate is 60%–98% when performed by an expert pituitary surgeon. There is a need for additional pharmacological interventions to control hypercortisolaemia, which are currently limited, in children and adolescents. In ph...

ea0025oc3.8 | Pituitary and thyroid | SFEBES2011

Assessment of the UK iodine status: a National Survey

Vanderpump Mark , Lazarus John , Smyth Peter , Burns Robert , Eggo Margaret , Han Thang , Williams Graham , Torlinska Barbara , Mullan Karen , Pearce Simon , Razvi Salman , Lean Mike , Aspray Emile Combet , Bannon Denise , Abraham Prakash , Vadia Bijay , Leese Graham , Laurberg Peter , Boelaert Kristien , Franklyn Jayne

Inadequate dietary iodine intake is the most common cause of preventable mental impairment worldwide and is defined by the WHO as a population median urinary iodine (UI) excretion <100 μg/l. No contemporary data are available for the UK according to the ICCIDD. The UK has no programme of food/salt iodination.We have performed a systematic assessment of the current UK iodine status in 14–15 years old schoolgirls. Seven hundred and eighty-fiv...

ea0038p290 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Influence of deuterium depleted water on indicators of prooxidant-antioxidant and detoxifying systems in experimental diabetes

Dzhimak Stepan , Basov Alexander , Fedulova Lilia , Kotenkova Elena

Studying the effect of deuterium depleted water (DDW) on isotope (D/H) composition and condition of an antioxidant-prooxidant plasma and lyophilized tissues of internal organs (liver, kidney) balance appropriate indicators in rats were compared: in group 1 (n=15) consumed mineralized water (150 ppm), which by a single intraperitoneal injection of alloxan (at a dose of 17 mg/100 g body weight) was established experimental model of diabetes; group 2 (n=15) cons...