Endocrine Abstracts

A 24-year-old woman complained about secondary amenorrhoea after stopping oral contraceptive whereas she wanted to be pregnant. Physical examination showed an android obesity with a non-progressive but major hirsutism. Endocrinological investigations eliminated pregnancy but revealed on different samples a high plasma testosterone level (from 2.15 to 2.77 ng/ml), in the tumoral range whereas DHEA-sulfate, delta4-androstendione, sex binding protein and prolactine were normal. S...

Introduction and objectives: Anxiety has a relevant impact on everyday life, including sexual life, and therefore is considered the final common pathway by which social, psychological and biological stressors negatively affect sexual functioning. The aim of this study is to define the psycho-biological correlates of free-floating anxiety in a large sample of patients complaining erectile dysfunction (ED) based sexual problems.Methods: We studied a consec...

Obesity is a major cause of chronic hypoventilation and/or obstructive sleep apnea syndrome (OSAS). Aim of this study was to evaluate the prevalence of pulmonary dysfunction and the relationship between OSAS and several clinical, functional and polysomnographics parameters in severely obese patients. 101 subjects (68 females and 33 males) aged 49.2±13.2 years (mean±S.D.), with BMI 46.8±6.5 Kg/m2 were enrolled. Sleep quality and daytime ...

We report a case of a 69-years-old woman who complained about progressive tachycardia, sweat and flush. Her single background was a breast cancer five years ago which was considered in remission. A first blood sample analysis showed an elevated rate of T4 whereas TSH was normal. An IgF1 assay was realised because of an acromegalic appearance and was abnormally high for sex and age. Further biological investigations confirmed central hyperthyroidism and acromegalia. Alpha subun...

Introduction: Osilodrostat is a potent oral 11β-hydroxylase inhibitor currently in Phase III clinical development for the treatment of Cushing’s syndrome (CS). The key pharmacokinetic (PK) properties, drug–drug interactions (DDIs), and population PK findings for osilodrostat in humans are summarized.Methods: Osilodrostat PK has been characterized in nine Phase I studies (healthy subjects and subjects with hepatic or renal impairment), two ...

Background: In children, Cushing’s disease (CD) presents with a combination of weight gain and slowed linear growth. First-line pituitary surgery is the treatment of choice for most patients. In paediatric patients, the transsphenoidal surgical success rate is 60%–98% when performed by an expert pituitary surgeon. There is a need for additional pharmacological interventions to control hypercortisolaemia, which are currently limited, in children and adolescents. In ph...