Searchable abstracts of presentations at key conferences in endocrinology

ea0036s1.1 | Symposia 1 Controversies in Vitamin D deficiency | BSPED2014

Consequences of maternal vitamin D deficiency

Cooper Cyrus

Osteoporosis is a skeletal disease characterised by low bone mass and susceptibility to fracture. Preventive strategies against osteoporotic fracture can be targeted throughout the life course. Although there is evidence to suggest that peak bone mass is inherited, current genetic markers are able to explain only a small proportion of the variation in individual bone mass or fracture risk. Evidence has begun to accrue that fracture risk might be modified by environmental influ...

ea0060nets5 | Diagnostic and Management Challenges in NETs | UKINETS2018

Nutrition support in GEP-NETs: an underestimated co-worker

Cooper Sheldon

Gastroenteropancreatic Neuroendocrine Tumours (NETs) may lead to gastrointestinal symptoms directly or as a result of their treatment, for example surgical resection and/or somatostatin analogues (SSA). When these symptoms become severe, patients may develop a reduced ability to successfully digest and absorb nutrients in the diet. This may be specific due the area of resection, e.g. vitamin B12, or secondary from medication, e.g. SSA induced pancreatic exocrine insufficiency ...

ea0031p305 | Pituitary | SFEBES2013

Gaining a better understanding of individual experiences of weight regulation in polycystic ovary syndrome

Cooper Gill

Polycystic ovary syndrome (PCOS) is an endocrinopathy affecting 5–10% of women. The PCOS symptomatology spectrum includes compromised fertility, dermatological conditions and metabolic dysregulation, the predominant cause of which is excess androgen production. PCOS is associated with increased risk of developing features of the metabolic syndrome which is exacerbated by the fact between 40 and 80% of PCOS diagnosed women are estimated to be obese. Achieving modest weight...

ea0029s69.1 | Current progress in the management of thyroid cancer | ICEECE2012

TSH suppression in differentiated thyroid cancer: how low should we go?

Cooper D.

Suppression of serum thyrotropin (TSH) is a cornerstone of thyroid cancer treatment, due to the tropic effects of TSH on thyroid cells. However, when deciding on the degree of TSH suppression during initial and long-term management, it is necessary to consider the aggressiveness of the cancer, as well as the potential for adverse effects induced by iatrogenic subclinical or overt hyperthyroidism. More aggressive TSH suppression is indicated in patients with high-risk disease o...

ea0028s6.1 | Inhibiting steroid enzymes to treat common diseases | SFEBES2012

Ageing gracefully - the role of 11β-HSD1

Cooper Mark

Although life expectancy is increasing, deterioration in many tissues with age can substantially impair quality of life. Muscle loss and weakness, decreased bone density leading to fractures, insulin resistance leading to diabetic complications and cognitive decline increase substantially with age. These features are also seen in patients treated with high doses of glucocorticoids raising the possibility that glucocorticoids could be involved in the ageing process. However, ci...

ea0025sig1.3 | Bone and mineral special interest group | SFEBES2011

Osteogenesis imperfecta

Cooper Mark

Osteogenesis imperfecta (OI) is a rare but serious genetic disorder of bone leading to increased fragility and greatly increased susceptibility to fracture. Some patients experience additional problems such as abnormally formed teeth, progressive deafness and scoliosis. The condition is divided into various subtypes with types I and IV being the commonest, type 2 is lethal in utero and type 3 is associated with most disability and deformity. Patients with OI typically h...

ea0015s29 | The endocrinology of critical illness | SFEBES2008

The glucocorticoid axis in critical illness: cause or effect?

Cooper Mark

Critical illness is associated with dramatic changes in the glucocorticoid axis. These changes occur at all levels of the axis, are most obvious in the increased serum levels of glucocorticoid but also occur within the tissue. Frank impairment of these responses (e.g. in Addison’s disease or with drugs that block adrenal hormone secretion) is associated with an adverse outcome but it has recently been suggested that many critically ill patients develop subtle abnormalitie...

ea0009s8 | Symposium 1: Endocrine complications of systemic disorders | BES2005

The endocrinology of critical care

Cooper M

Critical illness due to sepsis, trauma, surgery, organ failure or burns is associated with dramatic effects on most hormonal axes. Complex changes occur at the hypothalamic, pituitary, circulatory and tissue levels of hormone action. In the early stages of critical illness these changes appear to be adaptive but this may not be the case in prolonged illness. Common problems faced by endocrinologists are the recognition of pre-existing endocrine disorders in critically ill pati...

ea0073pl5.1 | Plenary 5: 1 Year in Bone | ECE2021

One year in osteoporosis

Cooper Cyrus

Osteoporosis constitutes a major public health problem through its association with age-related fractures. These fractures typically occur at the hip, spine and wrist. Our research into osteoporosis at the MRC Lifecourse Epidemiology Unit over three decades has characterised the epidemiology of these fractures, and contributed to the generation of preventive strategies against them throughout the lifecourse. Around 1 in 2 women and 1 in 5 men in the UK will sustain an osteopor...

ea0036oc6.5 | Oral Communications 6 | BSPED2014

Capillary beta-hydroxybutyrate levels reliably predicts clinical severity in established diabetes but not in first presentations of type 1 diabetes in children

Cooper Chris , Leach Miriam

Background: Near-patient capillary beta-hydroxybutyrate (BOHB) meters have been available for several years but evidence as to their clinical utility and reliability in children is still growing. Anecdotal evidence suggests that patients may have a significantly high level of capillary ketones but look clinically well, little evidence is available as to the kind of levels of blood ketones that paediatric patients can clinically compensate for. There is a move towards home bloo...