Endocrine Abstracts

Context: Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI). Objective: To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium, renin and clinical parameters. Design: Longitudinal study.Setting: Monocentric cohort.Patients: Data of 193 patients with PAI (130 autoi...

Introduction: The role of metformin in PCOS is very well known and several studies reported effects of thiazolidinediones and SGLT2 inhibitors on metabolic parametars in these patients.Objective: The aim of this study was to compare the effects of metformin, pioglitazone and empagliflozin treatment on metabolic control, hormonal imbalance, weight loss and ovulations in obese patients with PCOS and prediabetes.Methods: BMI, waist ci...

Introduction: No study has evaluated the effect of cytokines on the prototype beta chemokine (C-C motif) ligand (CCL)2 in Graves’ ophthalmopathy (GO), nor of peroxisome proliferator-activated receptor (PPAR)alpha activation on this chemokine secretion in fibroblasts or preadipocytes in GO.Design and methods: We have tested the interferon (IFN)gamma and tumor necrosis factor (TNF)alpha effect on CCL2, and for comparison on the prototype alpha chemoki...

Background: The presence of the metabolic syndrome (MS) increases cardiovascular morbidity and mortality but few data is available on the outcome in subjects with the MS and subclinical atherosclerosis.Aim: We aimed to assess cardio- and cerebro-vascular events in subjects with MS and subclinical atherosclerosis.Methods: We followed-up for 5 years 339 subjects with asymptomatic carotid intima-media thickness >0.9 mm, of whom 13...

Context. The routine measurement of serum calcitonin (CT) has been proposed for patients with nodular goiter (NG), to detect unsuspected medullary thyroid carcinoma (MTC) before surgery. Objective To assess the prevalence of hypercalcitoninemia and MTC in NG patients; to compare the ability of CT measurement and fine needle aspiration cytology (FNAC) to predict MTC; to identify age groups of NG patients who should be better candidates than others to undergo routine measurement...

Hypothyroid patients with gastric disorders require a higher dose of oral thyroxine (T4) to reach target serum TSH. In vitro evidence supports the notion that the variations of gastric pH may also interfere with T4 dissolution profile. The present study is aimed at confirming in vivo the supposed correlation between the gastric pH, directly measured during endoscopy, and the therapeutic dose of thyroxine using a controlled treatment schedule. A total of 61 tablet T4-t...

Background and aim: Information on incidence and prevalence of acromegaly usually originates from studies performed in referral endocrine care centers, whose catchment areas do not generally cover the entire population. Administrative databases can provide key information to assess the impact of acromegaly on patients and health systems. Our study aimed at estimating the prevalence and incidence data of acromegaly stratified by age and sex using data obtained in the Piedmont r...

Introduction: Medical therapy of Pancreatic neuroendocrine tumors (P-NETs) may take advantage from mammalian target of rapamycin (mTOR) inhibitors. However, so far, the extent of therapeutic response cannot be predicted.Aim: To investigate the possible predictors of sensitivity to mTOR inhibitors in P-NETs.Materials and methods: P-NET primary cultures were treated with IGF1 and/or Everolimus. Cell viability and caspase activity wer...

Parathyroid carcinoma (PC) is a rare neoplasia responsible for about 1% of primary hyperparathyroidism (PHPT). Differently from patients with its benign counterpart, the phenotype of these patients is characterized by severe PHPT and hypercalcemia. The aim of this study was to describe a series of PC casesrecorded in the regional cancer network of Piedmont and Valle d’Aosta, Italy (Rete Oncologica del Piemonte e della Valle d’Aosta) from 2007 to 2017, including 25 ...

Introduction: CLM29, a pyrazolo[3,4-d]pyrimidine compound, inhibits several targets (including the RET tyrosine kinase, epidermal growth factor receptor, vascular endothelial growth factor receptor and has an anti-angiogenic effect). Recently it has been shown to inhibit proliferation and migration in primary papillary dedifferentiated thyroid cancer cells. The aim of this study is to evaluate the anti-tumor activity of CLM29 in medullary thyroid cancer (MTC).<p c...