Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep313 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Vitamin D levels in obese adults and cardiovascular risk

Domingues Andreia , Oliveira Bruno , Correia Flora

Introduction: The prevalence of vitamin D deficiency is high, and yet still little recognized and treated. Cardiovascular diseases are the leading causes of morbidity and mortality worldwide and the emergence of evidence with the link suggesting an association between vitamin D deficiency and cardiovascular risk (CVR), it is pertinent to better understand this association.Objective: This study aimed to relate the levels of 25 (OH) D in obese patients wit...

ea0029p793 | Endocrine tumours and neoplasia | ICEECE2012

Refractory Seizures as a Presenting Feature of Insulinoma

Varma T. , Panchani R. , Saini A. , Correia P. , Nath G.

Introduction: Insulinomas are the commonest hormone-secreting tumor of gastrointestinal tract. Presentation is usually insidious with neuroglycopenia and fasting hypoglycemia. Many patients do not report adrenergic symptoms of hypoglycemia and present with neurological or psychiatric manifestations that often lead to misdiagnosis. The symptoms of insulinoma lack specificity, including various seizure disorders, personality change, bizarre behavior, amnesia, convulsions, and in...

ea0029p1194 | Obesity | ICEECE2012

Effects of bezafibrate treatment on pancreatic remodeling and insulin resistance in ovariectomized C57BL/6 mice fed high-fat diet

Faria T. , Ludgero-Correia A. , Aguilla M. , Mandarim-de-Lacerda C.

Introduction: Ovariectomized C57BL/6 mice are a good model to study the postmenopausal stage. It has been reported that high-fat diet (HFD) augments the body fat mass and insulin resistance (IR) in animal models. Goal of this study was to investigate the combined effects of ovariectomy (OVX) and HFD on insulin sensitivity and pancreatic remodeling in C57BL/6 mice treated with bezafibrate.Methods: Female C57BL/6 mice were subjected to surgical OVX and sur...

ea0026p612 | Clinical case reports | ECE2011

Iatrogenic hypoadrenalism: a case report

Mesquita J , Varela A , Magalhaes A , Correia F , Carvalho D

Introduction: Psoriasis is a chronic skin disease with a prevalence of 0.6 to 4.8%. Among the possible treatments, we highlight topic corticosteroids that can cause not only different local side effects (skin fragility and atrophy, striae, purpura, acne, telangiectasia, hypertrichosis) but also systemic side effects, including diabetes mellitus (DM), hypertension (HT), Cushing’s syndrome and hypothalamic–pituitary–adrenal (HHA) axis suppression.<p class="abs...

ea0049ep403 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The fatty acid profile in diabetic children

Castro-Correia Cintia , Sousa Sara , Norberto Sonia , Delerue-Matos Cristina , Domingues Valentina , Fontoura Manuel , Calhau Conceicao

Several studies have shown a link between pro-inflammatory activity and the presence or relative deficit of some fatty acids. A low amount of omega 3 fatty acids, appears to promote an inflammatory profile. The omega 6 fatty acids have also the same effect. It is well known that a chronic low-grade inflammation is associated to several diseases, namely, diabetes. The follow-up of children and young people with Type 1 diabetes involves the periodic evaluation of their lipidic p...

ea0049ep512 | Diabetes complications | ECE2017

Metabolic risk factors in adolescent girls with type 1 diabetes

Pinheiro Marta Isabel , Oliveira Juliana , Silva Rita Santos , Correia Cintia Castro , Fontoura Manuel

Background: Adolescent girls with type 1 diabetes (T1DM) have a higher incidence of metabolic risk factors like hypertension, dyslipidemia, non-alcoholic hepatic steatosis (NASH), abdominal adiposity and polycystic ovarian syndrome (PCOS) when compared with their non-diabetic peers. Moreover, metabolic risk factors seem to appear even in T1DM girls without overweight or obesity. We aimed to determine the prevalence of several metabolic risk factors in adolescent T1DM females, ...

ea0035p702 | Male reproduction | ECE2014

Effect of 17β-estradiol on germ cell apoptosis by modulating the expression of SCF/c-kit, FasL/FasR and regucalcin

Correia Sara , Alves Mario R , Martins Ana D , Cavaco Jose E , Oliveira Pedro F , Socorro Silvia

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

ea0070aep473 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Refeeding syndrome – an unexpected clinical case

Puga Francisca , Baptista Patrícia , França Margarida , Araújo Correia João

Refeeding syndrome can be defined as the potentially fatal shift in fluids and electrolytes that may occur after the reintroduction of feeding after a period of starvation or fasting in malnourished patients. The hallmark characteristic of refeeding syndrome is hypophosphatemia. However, the syndrome is complex and may also feature abnormal sodium and fluid balance, changes in glucose, protein and fat metabolism, hypokalemia, hypomagnesemia and thiamine deficiency. The underly...

ea0070ep308 | Pituitary and Neuroendocrinology | ECE2020

Insipidus diabetes and vaginal ulcers... evidence for the diagnosis of langerhans cell hypophysitis

Correia Sara , Melo Gustavo , Alves Helena , Almeida Lucia , João Oliveira Maria , Ramalho Diogo

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...

ea0032p927 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Therapeutic response to recombinat somatropin in children with isolated deficiency of GH

Belo Sandra , Nogueira Claudia , Corujeira Susana , Costa Carla , Castro-Correia Cintia , Fontoura Manuel

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...