Endocrine Abstracts

The thyroid gland regulates growth and metabolism by producing thyroid hormones in follicles composed of thyrocytes. So far, thyroid cells were thought to be a homogeneous population. To uncover genetic heterogeneity in the thyrocyte population and to molecularly characterize the non-thyrocyte cells surrounding mature follicles or follicles in development, we have developed single-cell transcriptome atlas of mouse and human thyroid organoids derived from pluripotent stem cells...

Induced overexpression of defined transcription factors has been shown to have a directing effect on the differentiation of embryonic stem cells (ESCs) into specific cell types. Nevertheless, protocols promoting coordinated self-assembly of differentiated cells into distinct morphological units with functional properties reminiscent of organs and tissues in vivo are still very sparse. Our group recently reported efficient rescue of hypothyroidism in athyroid mice tran...

The thyrotropin receptor (TSHr) is a glycoprotein hormone receptor controlling the thyroid growth and the thyroid hormones production, upon stimulation by its natural ligand, the thyrotropin hormone (TSH). In some pathological situations, this receptor is activated in the absence of TSH, either by autoantibodies from patients with Graves’ disease (an autoimmune thyroid disease where the TSHr is targeted and activated by autoantibodies), or by activating mutations (as obse...

S Hillier, University of Edinburgh, Edinburgh, United Kingdom AbstractSteve Hillier is Professor of Reproductive Endocrinology at the University of Edinburgh, where he has directed infertility laboratory services at the Royal Infirmary of Edinburgh and undertaken research at the Centre for Reproductive Biology for over 20 years. Previously (1982–1985), working with Robert (now Lord) Winston, he established the <i...

G Risbridger, Monash University, Melbourne, Australia AbstractProfessor Risbridger, a founding member of the Monash Institute of Medical Research, currently heads the Institute's Centre for Urological Research (CURe). She leads a team of investigators who aim to better understand prostate disease leading to better diagnosis and treatment of both benign and malignant prostate disease. Professor Risbridger is a Fulbright...

VKK Chatterjee, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom AbstractKrishna Chatterjee graduated from Cambridge and completed his clinical training in Oxford. He first trained in endocrinology at Hammersmith Hospital, London and subsequently undertook research in the Thyroid Unit at Massachusetts General Hospital, Boston. In 1990, he returned to Cambridge as a Wellcome Senior Clinical Res...

C Strasburger, Charite Campus Mitte, Berlin, Germany AbstractSince 2003 Christian J Strasburger has been Division Chief and Professor of Clinical Endocrinology at the Department of Medicine at Charité-Universitätsmedizin Berlin, Germany. He graduated from the Medizinische Universität Lübeck, Germany and trained in internal medicine and endocrinology at the Universities of Lübeck and Munich. He ...

The dichotomy between hormone recognition, by the ectodomain containing leucine-rich repeats (LRR), and activation of the G protein, by the rhodopsin-like serpentine portion, is a well established property of glycoprotein hormone receptors (GpHRs). Extensive site-directed mutagenesis experiments and direct structural data have fully confirmed that high affinity recognition of the hormones by their receptors was built within the structure of the LRRs. It is possible to transfor...

Organoids are tiny, self-organized three-dimensional versions of an organ that are produced in vitro. Human organoids offer unique opportunities to model the development, physiology, and diseases of human tissues while complementing animal models and reducing the need for animal testing. In the thyroid field, there is a lack of a functional human in vitro thyroid model which allows to further explore various aspects related to thyroid development and disease....

Recent studies suggest TSH inhibits bone remodeling, indicating that TSH deficiency rather than thyroid hormone excess could cause bone loss in thyrotoxicosis. The findings predict that TSH receptor (TSHR) stimulating antibodies (TSHRAb) should inhibit bone turnover, whereas Graves’ disease patients exhibit high bone turnover with increased fracture susceptibility. We characterized TSH-action in primary human and mouse osteoblasts and osteoclasts, and explored whether a p...