Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0011p905 | Thyroid | ECE2006

Pretreatment with rhTSH allows effective 131I therapy in patients with multinodular toxic goiter and low radioiodine uptake

Gietka-Czernel M , Jastrzebska H , Zgliczynski W , Wasniewska G , Wróblewska M , Wernic K , Cybulska B , Karpiska E

Aim: Estimation of the effectiveness of a single low dose 0.05 mg rhTSH in increasing radioiodine uptake (RAIU) before 131I therapy for multinodular toxic goiter with low initial RAIU.Patients: 24 patients (21 women, 3 men) with multinodular toxic goiter without prior antithyroid drug therapy. The initial 24 h RAIU was 21.1±8.44%; range, 6–39% and thyroid volume 64.14±22.49 ml; range, 24.8–109 ml.Meth...
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ea0077oc4.1 | Adrenal and Cardiovascular | SFEBES2021

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with Primary Hyperaldosteronism.

Sander Kerstin , Gendron Thibault , Cybulska Klaudia A. , Sirindil Faith , Zhou Jonhua , Kalber Tammy L. , Lythgoe Mark F. , Kurzawinski Tom R. , Brown Morris J. , Arstad Erik

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor,...
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ea0081oc13.1 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with primary hyperaldosteronism

Sander Kerstin , Kurzawinski Tom , Gendron Thibault , Cybulska Klaudia , Sirindil Fatih , Zhou Junhua , Kalber Tammy , Lythgoe Mark , Brown Morris , Williams Bryan , Arstad Erik

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor, [18...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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