Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1129 | Thyroid Cancer | ECE2014

The role of ATM–CHEK2–BRCA1 axis in determination of genetic predisposition and clinical presentation of papillary thyroid carcinoma

Wojcicka Anna , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Maciag Monika , Czajka Agnieszka , Dymecka Kinga , Kot Adam , Ploski Rafal , Jazdzewski Krystian

Background: Risk of developing papillary thyroid carcinoma (PTC), the most frequent thyroid malignancy, is elevated up to 8.6-fold in the first-degree relatives of PTC patients, what could be explained by polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer, polymorphisms in DNA repair genes are likely to affect this risk. Among the DNA repair proteins, the ATM–CHEK2–BRCA1 axis see...

ea0011p785 | Thyroid | ECE2006

Pathogenic mutations in gene RET in patients with medullary thyroid carcinoma found in Polish population

Paszko Z , Sromek M , Czetwertynska M , Czapczak D , Wisniewska A , Skasko E , Kozlowicz-Gudzinska I , Prokurat A , Chrupek M

Aim: The aim of this paper is to summarise the seven’s years of investigations on the frequency and kind of mutations witch occurred in gene RET in patients with medullary thyroid cancer.Methods: Within 330 subjects studied, there were 235 patients with RRT and 95 their healthy relatives. DNA was isolated from peripheral blood lymphocytes. The following exons of the gene RET were amplified by the PCR method: 10, 11, 13, 14, 15 and 16 a...

ea0035p591 | Endocrine tumours and neoplasia | ECE2014

Should unifocal papillary thyroid microcarcinoma be treated as much radically as multifocal one?

Guminska Anna , Bakula-Zalewska Elwira , Benke Malgorzata , Bruszewska Elzbieta , Czetwertynska Malgorzata , Dlugosinska Joanna , Garszel Anna , Godlewska Paulina , Musial Emilia , Niewiadomska Joanna , Dedecjus Marek

Introduction: Multifocal papillary thyroid microcarcinama (PTmC) has been considered as more aggressive than the unifocal one.Aim of the study: This paper aims to compare this two groups considering histopatological sign of aggressivity, presence of inflammation and radioiodine uptake.Materials and methods: The analysis concerned 81 patient with microcarcinoma (PTmC) selected from group of 961 (8%) diagnosed and treated in conventi...

ea0035p1139 | Thyroid Cancer | ECE2014

The effect of allelic variants of the thyroid hormone receptor β (THRB) gene on the incidence of papillary thyroid carcinoma

Wojcicka Anna , Roslon Marek , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Kot Adam , Ploski Rafal , Hromada-Judycka Aneta , Swiech Marta , Jazdzewski Krystian

Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system. Its heritability is the highest among common cancers, as evidenced by family-based studies. Thyroid hormone receptor β gene (THRB), a known tumor suppressor, is crucial for the proper thyroid function, therefore its polymorphisms are likely to affect the risk for thyroid cancer.Aim of the study: In order to identify alleles that might modify...